Neural activity in mediodorsal nucleus of thalamus in rats performing a working memory task

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Title
Neural activity in mediodorsal nucleus of thalamus in rats performing a working memory task
Author(s)
Jihyero Han; Ji Hyun Lee; Min Jung Kim; Min Whan Jung
Publication Date
2013-08
Journal
FRONTIERS IN NEURAL CIRCUITS, v.7, no.128, pp.1 - 10
Publisher
FRONTIERS RES FOUND
Abstract
Theneuralcircuitconsistingofmediodorsalnucleus(MDN)ofthalamusandprefrontalcortex(PFC)hasbeenimplicatedinworkingmemory.InordertoinvestigatewhetherandhowtherodentMDNprocessesworkingmemory-relatedsignals,werecordedactivityofsingleneuronsfromtheMDNinratsperformingadelayedspatialalternationtask.TheMDNconveyedsignificantneuralsignalsfortheanimal’spreviouslychosengoal(retrospectiveinformation)intheearlydelayperiod,butthesignalsdeterioratedgraduallyovertimesothattheybecameweaktowardtheendofthedelayperiod.Neuralsignalsfortheanimal’supcominggoalchoice(prospectiveinformation)wereevenweakerthanthoseforthepreviouslychosengoal.TheseresultsareincontrasttothefindinginmonkeysthatbothMDNandPFCpersistentlymaintaintask-relatedneuralsignalsthroughoutdelayperiod.OurresultsdonotsupportsustainedMDN-PFCinteractionsasageneralmechanismformediatingworkingmemoryacrossdifferentbehavioraltasksand/oranimalspecies.
URI
https://pr.ibs.re.kr/handle/8788114/1277
ISSN
1662-5110
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
Files in This Item:
2013-07-17-Frontiers in Neural Circuits-Neural activity in mediodorsal.pdfDownload

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