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뇌과학이미징연구단
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Multiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

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dc.contributor.authorBo-yong Park-
dc.contributor.authorKebets, Valeria-
dc.contributor.authorLariviere, Sara-
dc.contributor.authorHettwer, Meike D.-
dc.contributor.authorPaquola, Casey-
dc.contributor.authorvan Rooij, Daan-
dc.contributor.authorBuitelaar, Jan-
dc.contributor.authorFranke, Barbara-
dc.contributor.authorHoogman, Martine-
dc.contributor.authorSchmaal, Lianne-
dc.contributor.authorVeltman, Dick J.-
dc.contributor.authorvan den Heuvel, Odile-
dc.contributor.authorStein, Dan J.-
dc.contributor.authorAndreassen, Ole A.-
dc.contributor.authorChing, Christopher R. K.-
dc.contributor.authorTurner, Jessica-
dc.contributor.authorvan Erp, Theo G. M.-
dc.contributor.authorEvans, Alan C.-
dc.contributor.authorDagher, Alain-
dc.contributor.authorThomopoulos, Sophia, I-
dc.contributor.authorThompson, Paul M.-
dc.contributor.authorValk, Sofie L.-
dc.contributor.authorKirschner, Matthias-
dc.contributor.authorBernhardt, Boris C.-
dc.date.accessioned2023-01-26T02:45:49Z-
dc.date.available2023-01-26T02:45:49Z-
dc.date.created2022-10-29-
dc.date.issued2022-09-
dc.identifier.issn2399-3642-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12730-
dc.description.abstractIndividuals across six major psychiatric conditions from the ENIGMA consortium reveals a shared morphological effect, following a sensory-fugal axis, which is related to microstructural gradient and neurotransmitter axes. It is increasingly recognized that multiple psychiatric conditions are underpinned by shared neural pathways, affecting similar brain systems. Here, we carried out a multiscale neural contextualization of shared alterations of cortical morphology across six major psychiatric conditions (autism spectrum disorder, attention deficit/hyperactivity disorder, major depression disorder, obsessive-compulsive disorder, bipolar disorder, and schizophrenia). Our framework cross-referenced shared morphological anomalies with respect to cortical myeloarchitecture and cytoarchitecture, as well as connectome and neurotransmitter organization. Pooling disease-related effects on MRI-based cortical thickness measures across six ENIGMA working groups, including a total of 28,546 participants (12,876 patients and 15,670 controls), we identified a cortex-wide dimension of morphological changes that described a sensory-fugal pattern, with paralimbic regions showing the most consistent alterations across conditions. The shared disease dimension was closely related to cortical gradients of microstructure as well as neurotransmitter axes, specifically cortex-wide variations in serotonin and dopamine. Multiple sensitivity analyses confirmed robustness with respect to slight variations in analytical choices. Our findings embed shared effects of common psychiatric conditions on brain structure in multiple scales of brain organization, and may provide insights into neural mechanisms of transdiagnostic vulnerability.-
dc.language영어-
dc.publisherNATURE PORTFOLIO-
dc.titleMultiscale neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000860702800005-
dc.identifier.scopusid2-s2.0-85138981157-
dc.identifier.rimsid79094-
dc.contributor.affiliatedAuthorBo-yong Park-
dc.identifier.doi10.1038/s42003-022-03963-z-
dc.identifier.bibliographicCitationCOMMUNICATIONS BIOLOGY, v.5, no.1-
dc.relation.isPartOfCOMMUNICATIONS BIOLOGY-
dc.citation.titleCOMMUNICATIONS BIOLOGY-
dc.citation.volume5-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaLife Sciences & Biomedicine - Other Topics-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryBiology-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusHUMAN CEREBRAL-CORTEX-
dc.subject.keywordPlusBRAIN STRUCTURAL ABNORMALITIES-
dc.subject.keywordPlusAUTISM SPECTRUM DISORDERS-
dc.subject.keywordPlusTEMPORAL-LOBE EPILEPSY-
dc.subject.keywordPlusSURFACE-BASED ANALYSIS-
dc.subject.keywordPlusDE-NOVO MUTATIONS-
dc.subject.keywordPlusTHICKNESS ABNORMALITIES-
dc.subject.keywordPlusHIERARCHICAL TAXONOMY-
dc.subject.keywordPlusHIPPOCAMPAL SCLEROSIS-
dc.subject.keywordPlusDOPAMINE HYPOTHESIS-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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