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뇌과학이미징연구단
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Improved laminar specificity and sensitivity by combining SE and GE BOLD signals

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dc.contributor.authorSoHyun Han-
dc.contributor.authorSeulgi Eun-
dc.contributor.authorCho, HyungJoon-
dc.contributor.authorKamil Uludaǧ-
dc.contributor.authorSeong-Gi Kim-
dc.date.accessioned2023-01-26T02:28:25Z-
dc.date.available2023-01-26T02:28:25Z-
dc.date.created2022-11-29-
dc.date.issued2022-12-
dc.identifier.issn1053-8119-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12523-
dc.description.abstract© 2022 The Author(s)The most widely used gradient-echo (GE) blood oxygenation level-dependent (BOLD) contrast has high sensitivity, but low specificity due to draining vein contributions, while spin-echo (SE) BOLD approach at ultra-high magnetic fields is highly specific to neural active sites but has lower sensitivity. To obtain high specificity and sensitivity, we propose to utilize a vessel-size-sensitive filter to the GE-BOLD signal, which suppresses macrovascular contributions and to combine selectively retained microvascular GE-BOLD signals with the SE-BOLD signals. To investigate our proposed idea, fMRI with 0.8 mm isotropic resolution was performed on the primary motor and sensory cortices in humans at 7 T by implementing spin- and gradient-echo (SAGE) echo planar imaging (EPI) acquisition. Microvascular-passed sigmoidal filters were designed based upon the vessel-size-sensitive ΔR2*/ΔR2 value for retaining GE-BOLD signals originating from venous vessels with ≤ 45 μm and ≤ 65 μm diameter. Unlike GE-BOLD fMRI, the laminar profile of SAGE-BOLD fMRI with the vessel-size-sensitive filter peaked at ∼ 1.0 mm from the surface of the primary motor and sensory cortices, demonstrating an improvement of laminar specificity over GE-BOLD fMRI. Also, the functional sensitivity of SAGE BOLD at middle layers (0.75–1.5 mm) was improved by ∼ 80% to ∼100% when compared with SE BOLD. In summary, we showed that combined GE- and SE-BOLD fMRI with the vessel-size-sensitive filter indeed yielded improved laminar specificity and sensitivity and is therefore an excellent tool for high spatial resolution ultra-high filed (UHF)-fMRI studies for resolving mesoscopic functional units.-
dc.language영어-
dc.publisherAcademic Press Inc.-
dc.titleImproved laminar specificity and sensitivity by combining SE and GE BOLD signals-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000892197600005-
dc.identifier.scopusid2-s2.0-85141752822-
dc.identifier.rimsid79223-
dc.contributor.affiliatedAuthorSoHyun Han-
dc.contributor.affiliatedAuthorSeulgi Eun-
dc.contributor.affiliatedAuthorKamil Uludaǧ-
dc.contributor.affiliatedAuthorSeong-Gi Kim-
dc.identifier.doi10.1016/j.neuroimage.2022.119675-
dc.identifier.bibliographicCitationNeuroImage, v.264-
dc.relation.isPartOfNeuroImage-
dc.citation.titleNeuroImage-
dc.citation.volume264-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.relation.journalWebOfScienceCategoryNeuroimaging-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.subject.keywordPlusSPIN-ECHO BOLD-
dc.subject.keywordPlusOCULAR DOMINANCE COLUMNS-
dc.subject.keywordPlusGRADIENT-ECHO-
dc.subject.keywordPlusFUNCTIONAL MRI-
dc.subject.keywordPlusMAGNETIC-SUSCEPTIBILITY-
dc.subject.keywordPlusHIGH-RESOLUTION-
dc.subject.keywordPlusVESSEL SIZE-
dc.subject.keywordPlusVISUAL-CORTEX-
dc.subject.keywordPlusBLOOD-VOLUME-
dc.subject.keywordPlusHUMAN BRAIN-
dc.subject.keywordAuthorHigh resolution fMRI-
dc.subject.keywordAuthorLayer specificity and sensitivity-
dc.subject.keywordAuthorSE BOLD-
dc.subject.keywordAuthorUltra-high field-
dc.subject.keywordAuthorVessel-size-sensitive filter-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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