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Mari, Vellakkaran
분자활성 촉매반응 연구단
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Visible-Light-Induced C4-Selective Functionalization of Pyridinium Salts with Cyclopropanols

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Title
Visible-Light-Induced C4-Selective Functionalization of Pyridinium Salts with Cyclopropanols
Author(s)
Mari Vellakkaran; Taehwan Kim; Sungwoo Hong
Publication Date
2022-01
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.61, no.1
Publisher
WILEY-V C H VERLAG GMBH
Abstract
The site-selective C-H functionalization of heteroarenes is of considerable importance for streamlining the rapid modification of bioactive molecules. Herein, we report a general strategy for visible-light-induced beta-carbonyl alkylation at the C4 position of pyridines with high site selectivity using various cyclopropanols and N-amidopyridinium salts. In this process, hydrogen-atom transfer between the generated sulfonamidyl radicals and O-H bonds of cyclopropanols generates beta-carbonyl radicals, providing efficient access to synthetically valuable beta-pyridylated (aryl)ketones, aldehydes, and esters with broad functional-group tolerance. In addition, the mild method serves as an effective tool for the site-selective late-stage functionalization of complex and medicinally relevant molecules.
URI
https://pr.ibs.re.kr/handle/8788114/12076
DOI
10.1002/anie.202113658
ISSN
1433-7851
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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