BROWSE

Related Scientist

Daniel Roh, Junyeop's photo.

Daniel Roh, Junyeop
시냅스 뇌질환 연구단
more info

ITEM VIEW & DOWNLOAD

Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes

Cited 0 time in webofscience Cited 0 time in scopus
11 Viewed 0 Downloaded
Title
Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes
Author(s)
Kim, Junhyung; Junyeop Daniel Roh; Kim, Seongbin; Kang, Hyojin; Mihyun Bae; Eunjoon Kim
Publication Date
2022-03
Journal
Frontiers in Molecular Neuroscience, v.15
Publisher
Frontiers Media S.A.
Abstract
Copyright © 2022 Kim, Roh, Kim, Kang, Bae and Kim.SLC6A20A is a proline and glycine transporter known to regulate glycine homeostasis and NMDA receptor (NMDAR) function in the brain. A previous study found increases in ambient glycine levels and NMDA receptor-mediated synaptic transmission in the brains of Slc6a20a-haploinsufficient mice, but it remained unknown whether Slc6a20a deficiency leads to disease-related behavioral deficits in mice. Here, we report that Slc6a20a heterozygous and homozygous mutant mice display differential behavioral phenotypes in locomotor, repetitive behavioral, and spatial and fear memory domains. In addition, these mice show differential transcriptomic changes in synapse, ribosome, mitochondria, autism, epilepsy, and neuron-related genes. These results suggest that heterozygous and homozygous Slc6a20a deletions in mice lead to differential changes in behaviors and transcriptomes.
URI
https://pr.ibs.re.kr/handle/8788114/11985
DOI
10.3389/fnmol.2022.857820
ISSN
1662-5099
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse