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Yi, Jee Hyun
시냅스 뇌질환 연구단
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Variations in Commissural Input Processing Across Different Types of Cortical Projection Neurons

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Title
Variations in Commissural Input Processing Across Different Types of Cortical Projection Neurons
Author(s)
Jee Hyun Yi; Seo Yeon Choe; Min Whan Jung
Publication Date
2022-06
Journal
Cerebral Cortex, v.32, no.12, pp.2508 - 2520
Publisher
Oxford University Press (OUP)
Abstract
© The Author(s) 2021. To understand how incoming cortical inputs are processed by different types of cortical projection neurons in the medial prefrontal cortex, we compared intrinsic physiological properties of and commissural excitatory/inhibitory influences on layer 5 intratelencephalic (IT), layer 5 pyramidal tract (PT), and layers 2/3 IT projection neurons. We found that intrinsic physiological properties and commissural synaptic transmission varied across the three types of projection neurons. The rank order of intrinsic excitability was layer 5 PT > layer 5 IT > layers 2/3 IT neurons. Commissural connectivity was higher in layers 2/3 than layer 5 projection neurons, but commissural excitatory influence was stronger on layer 5 than layers 2/3 pyramidal neurons. Paired-pulse ratio was also greater in PT than IT neurons. These results indicate that commissural inputs activate deep layer PT neurons most preferentially and superficial layer IT neurons least preferentially. Deep layer PT neurons might faithfully transmit cortical input signals to downstream subcortical structures for reliable control of behavior, whereas superficial layer IT neurons might integrate cortical input signals from diverse sources in support of higher-order cognitive functions.
URI
https://pr.ibs.re.kr/handle/8788114/11930
DOI
10.1093/cercor/bhab361
ISSN
1047-3211
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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