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Yi, Jee Hyun
시냅스 뇌질환 연구단
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Variations in Commissural Input Processing Across Different Types of Cortical Projection Neurons

DC Field Value Language
dc.contributor.authorJee Hyun Yi-
dc.contributor.authorSeo Yeon Choe-
dc.contributor.authorMin Whan Jung-
dc.date.accessioned2022-07-28T04:42:43Z-
dc.date.available2022-07-28T04:42:43Z-
dc.date.created2021-12-10-
dc.date.issued2022-06-
dc.identifier.issn1047-3211-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11930-
dc.description.abstract© The Author(s) 2021. To understand how incoming cortical inputs are processed by different types of cortical projection neurons in the medial prefrontal cortex, we compared intrinsic physiological properties of and commissural excitatory/inhibitory influences on layer 5 intratelencephalic (IT), layer 5 pyramidal tract (PT), and layers 2/3 IT projection neurons. We found that intrinsic physiological properties and commissural synaptic transmission varied across the three types of projection neurons. The rank order of intrinsic excitability was layer 5 PT > layer 5 IT > layers 2/3 IT neurons. Commissural connectivity was higher in layers 2/3 than layer 5 projection neurons, but commissural excitatory influence was stronger on layer 5 than layers 2/3 pyramidal neurons. Paired-pulse ratio was also greater in PT than IT neurons. These results indicate that commissural inputs activate deep layer PT neurons most preferentially and superficial layer IT neurons least preferentially. Deep layer PT neurons might faithfully transmit cortical input signals to downstream subcortical structures for reliable control of behavior, whereas superficial layer IT neurons might integrate cortical input signals from diverse sources in support of higher-order cognitive functions.-
dc.language영어-
dc.publisherOxford University Press (OUP)-
dc.titleVariations in Commissural Input Processing Across Different Types of Cortical Projection Neurons-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000789248700001-
dc.identifier.scopusid2-s2.0-85132453123-
dc.identifier.rimsid76790-
dc.contributor.affiliatedAuthorJee Hyun Yi-
dc.contributor.affiliatedAuthorSeo Yeon Choe-
dc.contributor.affiliatedAuthorMin Whan Jung-
dc.identifier.doi10.1093/cercor/bhab361-
dc.identifier.bibliographicCitationCerebral Cortex, v.32, no.12, pp.2508 - 2520-
dc.relation.isPartOfCerebral Cortex-
dc.citation.titleCerebral Cortex-
dc.citation.volume32-
dc.citation.number12-
dc.citation.startPage2508-
dc.citation.endPage2520-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordPlusLAYER 5 NEURONS-
dc.subject.keywordPlusPREFRONTAL CORTEX-
dc.subject.keywordPlusCONNECTIVITY-
dc.subject.keywordPlusCIRCUIT-
dc.subject.keywordPlusINTERNEURONS-
dc.subject.keywordPlusNEOCORTEX-
dc.subject.keywordPlusDYNAMICS-
dc.subject.keywordAuthorcortical layers-
dc.subject.keywordAuthorcortico-cortical projections-
dc.subject.keywordAuthorintratelencephalic neurons-
dc.subject.keywordAuthorprefrontal cortex-
dc.subject.keywordAuthorpyramidal tract neurons-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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