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Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses

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Title
Addressing Environmental Challenges of Porphyrin Mixtures Obtained from Statistical Syntheses
Author(s)
Helen Hölzel; Maximilian Muth; Dominik Lungerich; Norbert Jux
Publication Date
2021-03
Journal
Chemistry methods, v.1, no.3, pp.142 - 147
Publisher
Wiley
Abstract
Syntheses of complex molecular mixtures on the preparative scale are often challenging steps for chemists, which go hand in hand with expensive purification steps. Herein, the preparation and isolation of unsymmetrically substituted porphyrins, obtained from statistical reactions between two benzaldehydes, were investigated. Therefore, a semi-automated modular process was developed to lower the consumable costs, save time, and reduce waste production. We utilized a monomode microwave reactor equipped with an autosampler, and a medium pressure liquid chromatography (MPLC) flash purification device, equipped with a UV/Vis detector and a re-usable glass column packed with SiO2. With this method, it was possible to synthesize and purify several statistical porphyrin mixtures, while simultaneously reducing the environmental factor (E-factor) significantly, compared to conventionally performed porphyrin syntheses. Our approach shows that a sustainable investigation of academically relevant low-symmetrical porphyrins can be carried out feasibly, without sacrificing invested time.
URI
https://pr.ibs.re.kr/handle/8788114/11758
DOI
10.1002/cmtd.202000055
ISSN
2628-9725
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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