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뇌과학이미징연구단
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Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex

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dc.contributor.authorValk, Sofie L.-
dc.contributor.authorXu, Ting-
dc.contributor.authorPaquola, Casey-
dc.contributor.authorBo-yong Park-
dc.contributor.authorBethlehem, Richard A. I.-
dc.contributor.authorVos de Wael, Reinder-
dc.contributor.authorRoyer, Jessica-
dc.contributor.authorMasouleh, Shahrzad Kharabian-
dc.contributor.authorBayrak, Şeyma-
dc.contributor.authorKochunov, Peter-
dc.contributor.authorYeo, B. T. Thomas-
dc.contributor.authorMargulies, Daniel-
dc.contributor.authorSmallwood, Jonathan-
dc.contributor.authorEickhoff, Simon B.-
dc.contributor.authorBernhardt, Boris C.-
dc.date.accessioned2022-06-08T02:10:28Z-
dc.date.available2022-06-08T02:10:28Z-
dc.date.created2022-05-23-
dc.date.issued2022-05-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11698-
dc.description.abstract© 2022, The Author(s).Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cognition and behavior. Here, we synthesize genetic, phylogenetic and cognitive analyses to understand how the macroscale organization of structure-function coupling across the cortex can inform its role in cognition. In humans, structure-function coupling was highest in regions of unimodal cortex and lowest in transmodal cortex, a pattern that was mirrored by a reduced alignment with heritable connectivity profiles. Structure-function uncoupling in macaques had a similar spatial distribution, but we observed an increased coupling between structure and function in association cortices relative to humans. Meta-analysis suggested regions with the least genetic control (low heritable correspondence and different across primates) are linked to social-cognition and autobiographical memory. Our findings suggest that genetic and evolutionary uncoupling of structure and function in different transmodal systems may support the emergence of complex forms of cognition.-
dc.language영어-
dc.publisherNature Research-
dc.titleGenetic and phylogenetic uncoupling of structure and function in human transmodal cortex-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000792848500017-
dc.identifier.scopusid2-s2.0-85129499530-
dc.identifier.rimsid78173-
dc.contributor.affiliatedAuthorBo-yong Park-
dc.identifier.doi10.1038/s41467-022-29886-1-
dc.identifier.bibliographicCitationNature Communications, v.13, no.1-
dc.relation.isPartOfNature Communications-
dc.citation.titleNature Communications-
dc.citation.volume13-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusMYELIN-
dc.subject.keywordPlusAREAS-
dc.subject.keywordPlusPARCELLATION-
dc.subject.keywordPlusALIGNMENT-
dc.subject.keywordPlusHERITABILITY-
dc.subject.keywordPlusNEUROANATOMY-
dc.subject.keywordPlusHUMAN CEREBRAL-CORTEX-
dc.subject.keywordPlusDEFAULT-MODE NETWORK-
dc.subject.keywordPlusHUMAN BRAIN-
dc.subject.keywordPlusEVOLUTION-
dc.subject.keywordAuthorHUMAN CEREBRAL-CORTEX-
dc.subject.keywordAuthorDEFAULT-MODE NETWORK-
dc.subject.keywordAuthorHUMAN BRAIN-
dc.subject.keywordAuthorEVOLUTION-
dc.subject.keywordAuthorMYELIN-
dc.subject.keywordAuthorAREAS-
dc.subject.keywordAuthorPARCELLATION-
dc.subject.keywordAuthorALIGNMENT-
dc.subject.keywordAuthorHERITABILITY-
dc.subject.keywordAuthorNEUROANATOMY-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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