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Chung, Chang Uk
시냅스 뇌질환 연구단
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Early and Late Corrections in Mouse Models of Autism Spectrum DisorderHighly Cited Paper

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Title
Early and Late Corrections in Mouse Models of Autism Spectrum Disorder
Author(s)
Changuk Chung; Wangyong Shin; Eunjoon Kim
Publication Date
2022-06
Journal
Biological Psychiatry, v.91, no.11, pp.934 - 944
Publisher
Elsevier Inc.
Abstract
© 2021 Society of Biological PsychiatryAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and repetitive symptoms. A key feature of ASD is early-life manifestations of symptoms, indicative of early pathophysiological mechanisms. In mouse models of ASD, increasing evidence indicates that there are early pathophysiological mechanisms that can be corrected early to prevent phenotypic defects in adults, overcoming the disadvantage of the short-lasting effects that characterize adult-initiated treatments. In addition, the results from gene restorations indicate that ASD-related phenotypes can be rescued in some cases even after the brain has fully matured. These results suggest that we need to consider both temporal and mechanistic aspects in studies of ASD models and carefully compare genetic and nongenetic corrections. Here, we summarize the early and late corrections in mouse models of ASD by genetic and pharmacological interventions and discuss how to better integrate these results to ensure efficient and long-lasting corrections for eventual clinical translation.
URI
https://pr.ibs.re.kr/handle/8788114/11617
DOI
10.1016/j.biopsych.2021.07.021
ISSN
0006-3223
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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