Microtubule-associated protein tau is essential for long-term depression in the hippocampus Highly Cited Paper

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Title
Microtubule-associated protein tau is essential for long-term depression in the hippocampus
Author(s)
Tetsuya Kimura; Daniel J. Whitcomb; Jihoon Jo; Philip Regan; Thomas Piers; Seonghoo Heo; Christopher Brown; Tsutomu Hashikawa; Miyuki Murayama; Heon Seok; Ioannis Sotiropoulos; Eunjoon Kim; Graham L. Collingridge; Akihiko Takashima; Kwangwook Cho
Publication Date
2014-01
Journal
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, v.369, no.369, pp.20130144 -
Publisher
ROYAL SOC
Abstract
The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer`s disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro, an effect that was replicated by RNAi knockdown of tau in vitro. We found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau. These observations demonstrate that tau has a critical physiological function in LTD.
URI
https://pr.ibs.re.kr/handle/8788114/1145
ISSN
0962-8436
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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