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분자활성촉매반응연구단
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Enantioselective functionalization at the C4 position of pyridinium salts through NHC catalysis

DC Field Value Language
dc.contributor.authorHangyeol Choi-
dc.contributor.authorGangadhar Rao Mathi-
dc.contributor.authorSeonghyeok Hong-
dc.contributor.authorSungwoo Hong-
dc.date.accessioned2022-05-25T04:33:50Z-
dc.date.accessioned2022-05-25T04:33:50Z-
dc.date.available2022-05-25T04:33:50Z-
dc.date.available2022-05-25T04:33:50Z-
dc.date.created2022-04-18-
dc.date.issued2022-04-
dc.identifier.issn2041-1723-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11440-
dc.description.abstract© 2022, The Author(s).A catalytic method for the enantioselective and C4-selective functionalization of pyridine derivatives is yet to be developed. Herein, we report an efficient method for the asymmetric β-pyridylations of enals that involve N-heterocyclic carbene (NHC) catalysis with excellent control over enantioselectivity and pyridyl C4-selectivity. The key strategy for precise stereocontrol involves enhancing interactions between the chiral NHC-bound homoenolate and pyridinium salt in the presence of hexafluorobenzene, which effectively differentiates the two faces of the homoenolate radical. Room temperature is sufficient for this transformation, and reaction efficiency is further accelerated by photo-mediation. This methodology exhibits broad functional group tolerance and enables facile access to a diverse range of enantioenriched β-pyridyl carbonyl compounds under mild and metal-free conditions.-
dc.language영어-
dc.publisherNature Research-
dc.titleEnantioselective functionalization at the C4 position of pyridinium salts through NHC catalysis-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000777408600053-
dc.identifier.scopusid2-s2.0-85127454860-
dc.identifier.rimsid78064-
dc.contributor.affiliatedAuthorHangyeol Choi-
dc.contributor.affiliatedAuthorGangadhar Rao Mathi-
dc.contributor.affiliatedAuthorSeonghyeok Hong-
dc.contributor.affiliatedAuthorSungwoo Hong-
dc.identifier.doi10.1038/s41467-022-29462-7-
dc.identifier.bibliographicCitationNature Communications, v.13, no.1-
dc.relation.isPartOfNature Communications-
dc.citation.titleNature Communications-
dc.citation.volume13-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusBETA-HYDROXYLATION-
dc.subject.keywordPlusELECTRON-TRANSFER-
dc.subject.keywordPlusLIGHT-
dc.subject.keywordPlusARYLATION-
dc.subject.keywordPlusALDEHYDES-
dc.subject.keywordPlusRADICALS-
dc.subject.keywordPlusDESIGN-
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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