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뇌과학이미징연구단
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Cerebrospinal Fluid-philic and Biocompatibility-Enhanced Soft Cranial Window for Long-Term in Vivo Brain Imaging

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dc.contributor.authorKim, Jong Uk-
dc.contributor.authorPark, Hyejin-
dc.contributor.authorOk, Jehyung-
dc.contributor.authorLee, Juheon-
dc.contributor.authorJung, Woojin-
dc.contributor.authorKim, Jiwon-
dc.contributor.authorKim, Jaehyun-
dc.contributor.authorKim, Suhyeon-
dc.contributor.authorKim, Yong Ho-
dc.contributor.authorMinah Suh-
dc.contributor.authorKim, Tae-Il-
dc.date.accessioned2022-05-25T04:33:09Z-
dc.date.accessioned2022-05-25T04:33:09Z-
dc.date.available2022-05-25T04:33:09Z-
dc.date.available2022-05-25T04:33:09Z-
dc.date.created2022-04-26-
dc.date.issued2022-04-
dc.identifier.issn1944-8244-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/11432-
dc.description.abstract© 2022 American Chemical Society.Soft, transparent poly(dimethyl siloxane) (PDMS)-based cranial windows in animal models have created many opportunities to investigate brain functions with multiple in vivo imaging modalities. However, due to the hydrophobic nature of PDMS, the wettability by cerebrospinal fluid (CSF) is poor, which may cause air bubble trapping beneath the window during implantation surgery, and favorable heterogeneous bubble nucleation at the interface between hydrophobic PDMS and CSF. This may result in excessive growth of the entrapped bubble under the soft cranial window. Herein, to yield biocompatibility-enhanced, trapped bubble-minimized, and soft cranial windows, this report introduces a CSF-philic PDMS window coated with hydroxyl-enriched poly(vinyl alcohol) (PVA) for long-term in vivo imaging. The PVA-coated PDMS (PVA/PDMS) film exhibits a low contact angle θACA (33.7 ± 1.9°) with artificial CSF solution and maintains sustained CSF-philicity. The presence of the PVA layer achieves air bubble-free implantation of the soft cranial window, as well as induces the formation of a thin wetting film that shows anti-biofouling performance through abundant water molecules on the surface, leading to long-term optical clarity. In vivo studies on the mice cortex verify that the soft and CSF-philic features of the PVA/PDMS film provide minimal damage to neuronal tissues and attenuate immune response. These advantages of the PVA/PDMS window are strongly correlated with the enhancement of cortical hemodynamic changes and the local field potential recorded through the PVA/PDMS film, respectively. This collection of results demonstrates the potential for future microfluidic platforms for minimally invasive CSF extraction utilizing a CSF-philic fluidic passage.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleCerebrospinal Fluid-philic and Biocompatibility-Enhanced Soft Cranial Window for Long-Term in Vivo Brain Imaging-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000800295400016-
dc.identifier.scopusid2-s2.0-85127914316-
dc.identifier.rimsid78088-
dc.contributor.affiliatedAuthorMinah Suh-
dc.identifier.doi10.1021/acsami.2c01929-
dc.identifier.bibliographicCitationACS Applied Materials and Interfaces, v.14, no.13, pp.15035 - 15046-
dc.relation.isPartOfACS Applied Materials and Interfaces-
dc.citation.titleACS Applied Materials and Interfaces-
dc.citation.volume14-
dc.citation.number13-
dc.citation.startPage15035-
dc.citation.endPage15046-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.subject.keywordPlusAIR BUBBLE-
dc.subject.keywordPlusNANOBUBBLES-
dc.subject.keywordPlusSURFACE-
dc.subject.keywordPlusWATER-
dc.subject.keywordPlusINTERLEUKIN-1-
dc.subject.keywordPlusPERMEABILITY-
dc.subject.keywordPlusASTROCYTES-
dc.subject.keywordPlusINTERFACE-
dc.subject.keywordPlusMICROGLIA-
dc.subject.keywordPlusSTABILITY-
dc.subject.keywordAuthorcerebrospinal fluid (CSF)-
dc.subject.keywordAuthorcerebrospinal fluid-philic-
dc.subject.keywordAuthorpoly(dimethyl siloxane) (PDMS)-
dc.subject.keywordAuthorpoly(vinyl alcohol) (PVA)-
dc.subject.keywordAuthorsoft cranial window-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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