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Yujeong, Kang
시냅스 뇌질환 연구단
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A role of anterior cingulate cortex in the emergence of worker-parasite relationship

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Title
A role of anterior cingulate cortex in the emergence of worker-parasite relationship
Author(s)
Ahn, Soyoun; Yujeong Kang; Jong Won Lee; Jeong, Se Jin; Lee, Yoo Jin; Lee, Soomin; Kim, Jeongyeon; Koo, Ja Wook; Kim, Jeansok J.; Min Whan Jung
Publication Date
2021-11-30
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.118, no.48
Publisher
NATL ACAD SCIENCES
Abstract
© Ahn et al. We studied the brain mechanisms underlying action selection in a social dilemma setting in which individuals' effortful gains are unfairly distributed among group members. A stable "worker-parasite" relationship developed when three individually operant-conditioned rats were placed together in a Skinner box equipped with response lever and food dispenser on opposite sides. Specifically, one rat, the "worker," engaged in lever-pressing while the other two "parasitic" rats profited from the worker's effort by crowding the feeder in anticipation of food. Anatomically, c-Fos expression in the anterior cingulate cortex (ACC) was significantly higher in worker rats than in parasite rats. Functionally, ACC inactivation suppressed the worker's lever-press behavior drastically under social, but only mildly under individual, settings. Transcriptionally, GABA(A) receptor- and potassium channel-related messenger RNA expressions were reliably lower in the worker's, relative to parasite's, ACC. These findings indicate the requirement of ACC activation for the expression of exploitable, effortful behavior, which could be mediated by molecular pathways involving GABA(A) receptor/potassium channel proteins.
URI
https://pr.ibs.re.kr/handle/8788114/10873
DOI
10.1073/pnas.2111145118
ISSN
0027-8424
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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