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Extra-basal ganglia iron content and non-motor symptoms in drug-naïve, early Parkinson’s disease

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dc.contributor.authorKim, Minkyeong-
dc.contributor.authorSeulki Yoo-
dc.contributor.authorKim, Doyeon-
dc.contributor.authorCho, Jin Whan-
dc.contributor.authorKim, Ji Sun-
dc.contributor.authorAhn, Jong Hyun-
dc.contributor.authorMun, Jun Kyu-
dc.contributor.authorChoi, Inyoung-
dc.contributor.authorSeung-Kyun Lee-
dc.contributor.authorYoun, Jinyoung-
dc.date.accessioned2021-12-13T00:50:02Z-
dc.date.available2021-12-13T00:50:02Z-
dc.date.created2021-05-27-
dc.date.issued2021-12-
dc.identifier.issn1590-1874-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10832-
dc.description.abstract© 2021, The Author(s).Background: Although iron dyshomeostasis is associated with Parkinson’s disease (PD) pathogenesis, the relationship between iron deposition and non-motor involvement in PD is not fully understood. In this study, we investigated basal ganglia and extra-basal ganglia system iron contents and their correlation with non-motor symptoms in drug-naïve, early-stage PD patients. Methods: We enrolled 14 drug-naïve, early-stage PD patients and 12 age/sex-matched normal controls. All participants underwent brain magnetic resonance imaging to obtain the effective transverse relaxation rate (R2*) and quantitative susceptibility mapping (QSM). Deep brain structures, including the nucleus accumbens, caudate nucleus, putamen, globus pallidus, thalamus, hippocampus, and amygdala, were delineated using the FSL-FIRST; the substantia nigra, red nucleus, and dentate nucleus were segmented manually. Inter-group differences in R2* and QSM values, as well as their association with clinical parameters of PD, were investigated. Results: Substantia nigra and putamen R2* values were significantly higher in PD patients than in normal controls, despite no significant difference in QSM values. Regarding the non-motor symptom scales, PD sleep scale score negatively correlated with R2* values in the red nucleus and right amygdala, Scales for Outcomes in Parkinson’s disease-Autonomic scores were positively correlated with R2* values in the right amygdala and left hippocampus, and cardiovascular sub-score of Non-Motor Symptoms Scale for PD was positively associated with the QSM value in the left hippocampus. Conclusion: In this study, iron content in the extra-basal ganglia system was significantly correlated with non-motor symptoms, especially sleep problems and dysautonomia, even in early-stage PD.-
dc.language영어-
dc.publisherSpringer-Verlag Italia s.r.l.-
dc.titleExtra-basal ganglia iron content and non-motor symptoms in drug-naïve, early Parkinson’s disease-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000640760700001-
dc.identifier.scopusid2-s2.0-85104766080-
dc.identifier.rimsid75695-
dc.contributor.affiliatedAuthorSeulki Yoo-
dc.contributor.affiliatedAuthorSeung-Kyun Lee-
dc.identifier.doi10.1007/s10072-021-05223-0-
dc.identifier.bibliographicCitationNeurological Sciences, v.42, no.12, pp.5297 - 5304-
dc.relation.isPartOfNeurological Sciences-
dc.citation.titleNeurological Sciences-
dc.citation.volume42-
dc.citation.number12-
dc.citation.startPage5297-
dc.citation.endPage5304-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalWebOfScienceCategoryClinical Neurology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.subject.keywordAuthorIron-
dc.subject.keywordAuthorNon-motor-
dc.subject.keywordAuthorParkinson’s disease-
dc.subject.keywordAuthorQuantitative susceptibility mapping-
dc.subject.keywordAuthorR2*-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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