BROWSE

Related Scientist

Park, Joo Min's photo.

Park, Joo Min
인지 및 사회성 연구단
more info

ITEM VIEW & DOWNLOAD

Homer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome

DC Field Value Language
dc.contributor.authorLin, Raozhou-
dc.contributor.authorLearman, Lisa N.-
dc.contributor.authorBangash, M. Ali-
dc.contributor.authorMelnikova, Tatiana-
dc.contributor.authorLeyder, Erica-
dc.contributor.authorReddy, Sai C.-
dc.contributor.authorNaidoo, Nirinjini-
dc.contributor.authorJoo Min Park-
dc.contributor.authorSavonenko, Alena-
dc.contributor.authorWorley, Paul F.-
dc.date.accessioned2021-11-30T05:50:00Z-
dc.date.available2021-11-30T05:50:00Z-
dc.date.created2021-11-29-
dc.date.issued2021-11-16-
dc.identifier.issn2211-1247-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10743-
dc.description.abstractMutations of SHANK3 cause Phelan-McDermid syndrome (PMS), and these individuals can exhibit sensitivity to stress, resulting in behavioral deterioration. Here, we examine the interaction of stress with genotype using a mouse model with face validity to PMS. In Shank3(Delta C/+) mice, swim stress produces an altered transcriptomic response in pyramidal neurons that impacts genes and pathways involved in synaptic function, signaling, and protein turnover. Homer1a, which is part of the Shank3-mGluR-N-methyl-D-aspartate (NMDA) receptor complex, is super-induced and is implicated in the stress response because stress-induced social deficits in Shank3(Delta C/+) mice are mitigated in Shank3(Delta C/+);Homer1a(-/-) mice. Several lines of evidence demonstrate that Shank3 expression is regulated by Homer1a in competition with crosslinking forms of Homer, and consistent with this model, Shank3 expression and function that are reduced in Shank3(Delta C/+) mice are rescued in Shank3(Delta C/+);Homer1a(-/-) mice. Studies highlight the interaction between stress and genetics and focus attention on activity-dependent changes that may contribute to pathogenesis.-
dc.language영어-
dc.publisherCELL PRESS-
dc.titleHomer1a regulates Shank3 expression and underlies behavioral vulnerability to stress in a model of Phelan-McDermid syndrome-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000720347900002-
dc.identifier.scopusid2-s2.0-85119589289-
dc.identifier.rimsid76764-
dc.contributor.affiliatedAuthorJoo Min Park-
dc.identifier.doi10.1016/j.celrep.2021.110014-
dc.identifier.bibliographicCitationCELL REPORTS, v.37, no.7-
dc.relation.isPartOfCELL REPORTS-
dc.citation.titleCELL REPORTS-
dc.citation.volume37-
dc.citation.number7-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusAUTISTIC-LIKE BEHAVIORS-
dc.subject.keywordPlusMESSENGER-RNA-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusCORTISOL-
dc.subject.keywordPlusDEFICITS-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusPLASTICITY-
dc.subject.keywordPlusCHILDREN-
dc.subject.keywordAuthorHomer1a-
dc.subject.keywordAuthorNMDAR-
dc.subject.keywordAuthorPhelan-McDermid syndrome-
dc.subject.keywordAuthorShank3-
dc.subject.keywordAuthorautism-
dc.subject.keywordAuthorsocial behavior-
dc.subject.keywordAuthorstress-
dc.subject.keywordAuthorsynapse-
Appears in Collections:
Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse