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Impact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities

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dc.contributor.authorLee, Na Kyeong-
dc.contributor.authorWang, Chi-Pin James-
dc.contributor.authorLim, Jaesung-
dc.contributor.authorPark, Wooram-
dc.contributor.authorKwon, Ho-Keun-
dc.contributor.authorKim, Se-Na-
dc.contributor.authorKim, Tae-Hyung-
dc.contributor.authorChun Gwon Park-
dc.date.accessioned2021-11-02T01:30:00Z-
dc.date.available2021-11-02T01:30:00Z-
dc.date.created2021-11-01-
dc.date.issued2021-08-16-
dc.identifier.issn2196-5404-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10539-
dc.description.abstract© 2021, The Author(s).Antibodies have been widely used to provide targeting ability and to enhance bioactivity owing to their high specificity, availability, and diversity. Recent advances in biotechnology and nanotechnology permit site-specific engineering of antibodies and their conjugation to the surfaces of nanoparticles (NPs) in various orientations through chemical conjugations and physical adhesions. This study proposes the conjugation of poly(lactic-co-glycolic acid) (PLGA) NPs with antibodies by using two distinct methods, followed by a comparison between the cell-targeting efficiencies of both techniques. Full-length antibodies were conjugated to the PLGA-poly(ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) NPs through the conventional carbodiimide coupling reaction, and f(ab′)2 antibody fragments were conjugated to the PLGA-poly(ethylene glycol)-maleimide(PLGA-PEG-Mal) NPs through interactions between the f(ab′)2 fragment thiol groups and the maleimide located on the nanoparticle surface. The results demonstrate that the PLGA nanoparticles conjugated with the f(ab′)2 antibody fragments had a higher targeting efficiency in vitro and in vivo than that of the PLGA nanoparticles conjugated with the full-length antibodies. The results of this study can be built upon to design a delivery technique for drugs through biocompatible nanoparticles.-
dc.language영어-
dc.publisherKorea Nano Technology Research Society-
dc.titleImpact of the conjugation of antibodies to the surfaces of polymer nanoparticles on the immune cell targeting abilities-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000686664600001-
dc.identifier.scopusid2-s2.0-85112709036-
dc.identifier.rimsid76550-
dc.contributor.affiliatedAuthorChun Gwon Park-
dc.identifier.doi10.1186/s40580-021-00274-7-
dc.identifier.bibliographicCitationNano Convergence, v.8, no.1-
dc.relation.isPartOfNano Convergence-
dc.citation.titleNano Convergence-
dc.citation.volume8-
dc.citation.number1-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPhysics-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.subject.keywordPlusMONOCLONAL-ANTIBODIES-
dc.subject.keywordPlusTHERAPEUTICS-
dc.subject.keywordPlusSTRATEGIES-
dc.subject.keywordAuthorAntibody Conjugation-
dc.subject.keywordAuthorCarbodiimide coupling-
dc.subject.keywordAuthorMaleimide-thiol reaction-
dc.subject.keywordAuthorNanoparticles-
dc.subject.keywordAuthorTarget drug delivery-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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