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STING facilitates nuclear import of herpesvirus genome during infection

DC Field Value Language
dc.contributor.authorYujin Hong-
dc.contributor.authorHeena Jeong-
dc.contributor.authorKiwon Park-
dc.contributor.authorSungwon Lee-
dc.contributor.authorShim, Jae Youn-
dc.contributor.authorHyewon Kim-
dc.contributor.authorYang Song-
dc.contributor.authorSeowoo Park-
dc.contributor.authorPark, Hye Yoon-
dc.contributor.authorV. Narry Kim-
dc.contributor.authorKwangseog Ahn-
dc.date.accessioned2021-09-01T01:30:07Z-
dc.date.accessioned2021-09-01T01:30:07Z-
dc.date.available2021-09-01T01:30:07Z-
dc.date.available2021-09-01T01:30:07Z-
dc.date.created2021-08-26-
dc.date.issued2021-08-17-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10176-
dc.description.abstract© 2021 National Academy of Sciences. All rights reserved.Once inside the host cell, DNA viruses must overcome the physical barrier posed by the nuclear envelope to establish a successful infection. The mechanism underlying this process remains unclear. Here, we show that the herpesvirus exploits the immune adaptor stimulator of interferon genes (STING) to facilitate nuclear import of the viral genome. Following the entry of the viral capsid into the cell, STING binds the viral capsid, mediates capsid docking to the nuclear pore complex via physical interaction, and subsequently enables accumulation of the viral genome in the nucleus. Silencing STING in human cytomegalovirus (HCMV)-susceptible cells inhibited nuclear import of the viral genome and reduced the ensuing viral gene expression. Overexpressing STING increased the host cell's susceptibility to HCMV and herpes simplex virus 1 by improving the nuclear delivery of viral DNA at the early stage of infection. These observations suggest that the proviral activity of STING is conserved and exploited by the herpesvirus family. Intriguingly, in monocytes, which act as latent reservoirs of HCMV, STING deficiency negatively regulated the establishment of HCMV latency and reactivation. Our findings identify STING as a proviral host factor regulating latency and reactivation of herpesviruses.-
dc.language영어-
dc.publisherNational Academy of Sciences-
dc.titleSTING facilitates nuclear import of herpesvirus genome during infection-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000689727600003-
dc.identifier.scopusid2-s2.0-85112475577-
dc.identifier.rimsid76295-
dc.contributor.affiliatedAuthorYujin Hong-
dc.contributor.affiliatedAuthorHeena Jeong-
dc.contributor.affiliatedAuthorKiwon Park-
dc.contributor.affiliatedAuthorSungwon Lee-
dc.contributor.affiliatedAuthorHyewon Kim-
dc.contributor.affiliatedAuthorYang Song-
dc.contributor.affiliatedAuthorSeowoo Park-
dc.contributor.affiliatedAuthorV. Narry Kim-
dc.contributor.affiliatedAuthorKwangseog Ahn-
dc.identifier.doi10.1073/pnas.2108631118-
dc.identifier.bibliographicCitationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.118, no.33-
dc.relation.isPartOfPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.citation.titlePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.citation.volume118-
dc.citation.number33-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalWebOfScienceCategoryMultidisciplinary Sciences-
dc.subject.keywordPlusHUMAN CYTOMEGALOVIRUS-INFECTION-
dc.subject.keywordPlusHOST-CELL PERMISSIVENESS-
dc.subject.keywordPlusPORE COMPLEX-
dc.subject.keywordPlusVIRUS-
dc.subject.keywordPlusSTIMULATOR-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusBINDING-
dc.subject.keywordAuthorHCMV-
dc.subject.keywordAuthornuclear import-
dc.subject.keywordAuthorcell susceptibility-
dc.subject.keywordAuthorSTING-
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Center for RNA Research(RNA 연구단) > 1. Journal Papers (저널논문)
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