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Improvement of sensitivity and specificity for laminar BOLD fMRI with double spin-echo EPI in humans at 7 T

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dc.contributor.authorSoHyun Han-
dc.contributor.authorSeulgi Eun-
dc.contributor.authorCho, HyungJoon-
dc.contributor.authorKâmil Uludaǧ-
dc.contributor.authorSeong-Gi Kim-
dc.date.accessioned2021-08-31T01:50:03Z-
dc.date.accessioned2021-08-31T01:50:03Z-
dc.date.available2021-08-31T01:50:03Z-
dc.date.available2021-08-31T01:50:03Z-
dc.date.created2021-08-26-
dc.date.issued2021-11-01-
dc.identifier.issn1053-8119-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/10173-
dc.description.abstract© 2021Mapping mesoscopic cortical functional units such as columns or laminae is increasingly pursued by ultra-high field (UHF) functional magnetic resonance imaging (fMRI). The most popular approach for high-resolution fMRI is currently gradient-echo (GE) blood oxygenation level-dependent (BOLD) fMRI. However, its spatial accuracy is reduced due to its sensitivity to draining vessels, including pial veins, whereas spin-echo (SE) BOLD signal is expected to have higher spatial accuracy, albeit with lower sensitivity than the GE-BOLD signal. Here, we introduce a new double spin-echo (dSE) echo-planar imaging (EPI) method to improve the sensitivity of SE-BOLD contrast by averaging two spin-echoes using three radiofrequency pulses. Human fMRI experiments were performed with slices perpendicular to the central sulcus between motor and sensory cortices at 7 T during fist-clenching with touching. First, we evaluated the feasibility of single-shot dSE-EPI for BOLD fMRI with 1.5 mm isotropic resolution and found that dSE-BOLD fMRI has higher signal-to-noise ratio (SNR), temporal SNR (tSNR), and higher functional sensitivity than conventional SE-BOLD fMRI. Second, to investigate the laminar specificity of dSE-BOLD fMRI, we implemented a multi-shot approach to achieve 0.8-mm isotropic resolution with sliding-window reconstruction. Unlike GE-BOLD fMRI, the cortical profile of dSE-BOLD fMRI peaked at ~ 1.0 mm from the surface of the primary motor and sensory cortices, demonstrating an improvement of laminar specificity in humans over GE-BOLD fMRI. The proposed multi-shot dSE-EPI method is viable for high spatial resolution UHF-fMRI studies in the pursuit of resolving mesoscopic functional units.-
dc.language영어-
dc.publisherAcademic Press Inc.-
dc.titleImprovement of sensitivity and specificity for laminar BOLD fMRI with double spin-echo EPI in humans at 7 T-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000693400400006-
dc.identifier.scopusid2-s2.0-85111493805-
dc.identifier.rimsid76247-
dc.contributor.affiliatedAuthorSoHyun Han-
dc.contributor.affiliatedAuthorSeulgi Eun-
dc.contributor.affiliatedAuthorKâmil Uludaǧ-
dc.contributor.affiliatedAuthorSeong-Gi Kim-
dc.identifier.doi10.1016/j.neuroimage.2021.118435-
dc.identifier.bibliographicCitationNEUROIMAGE, v.241-
dc.relation.isPartOfNEUROIMAGE-
dc.citation.titleNEUROIMAGE-
dc.citation.volume241-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.relation.journalWebOfScienceCategoryNeuroimaging-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.subject.keywordPlusCEREBRAL BLOOD-VOLUME-
dc.subject.keywordPlusOCULAR DOMINANCE COLUMNS-
dc.subject.keywordPlusGRADIENT-ECHO-
dc.subject.keywordPlusHUMAN BRAIN-
dc.subject.keywordPlusHIGH-FIELD-
dc.subject.keywordPlusMAGNETIC-SUSCEPTIBILITY-
dc.subject.keywordPlusSPATIAL-RESOLUTION-
dc.subject.keywordPlusFUNCTIONAL MRI-
dc.subject.keywordPlusCONTRAST SENSITIVITY-
dc.subject.keywordPlusSIGNAL CHANGES-
dc.subject.keywordAuthorHigh resolution fMRI-
dc.subject.keywordAuthorSpin-echo BOLD-
dc.subject.keywordAuthorUltra-high field-
dc.subject.keywordAuthorLayer specificity-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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