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Kim, Eunjoon
시냅스 뇌질환 연구단
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IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype

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Title
IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype
Author(s)
Hayano, Yasufumi; Ishino, Yugo; Hyun, Jung Ho; Orozco, Carlos G.; Steinecke, Andre; Potts, Elizabeth; Oisi, Yasuhiro; Thomas, Connon, I; Guerrero-Given, Debbie; Eunjoon Kim; Kwon, Hyung-Bae; Kamasawa, Naomi; Taniguchi, Hiroki
Publication Date
2021-07
Journal
SCIENCE ADVANCES, v.7, no.29
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
The most prominent structural hallmark of the mammalian neocortical circuitry is the layer-based organization of specific cell types and synaptic inputs. Accordingly, cortical inhibitory interneurons (INs), which shape local network activity, exhibit subtype-specific laminar specificity of synaptic outputs. However, the underlying molecular mechanisms remain unknown. Here, we demonstrate that Immunoglobulin Superfamily member 11 (IgSF11) homophilic adhesion proteins are preferentially expressed in one of the most distinctive IN subtypes, namely, chandelier cells (ChCs) that specifically innervate axon initial segments of pyramidal neurons (PNs), and their synaptic laminar target. Loss-of-function experiments in either ChCs or postsynaptic cells revealed that IgSF11 is required for ChC synaptic development in the target layer. While overexpression of IgSF11 in ChCs enlarges ChC presynaptic boutons, expressing IgSF11 in nontarget layers induces ectopic ChC synapses. These findings provide evidence that synapse-promoting adhesion proteins, highly localized to synaptic partners, determine the layer-specific synaptic connectivity of the cortical IN subtype.
URI
https://pr.ibs.re.kr/handle/8788114/10069
DOI
10.1126/sciadv.abf1600
ISSN
2375-2548
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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