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JEONG, Huijeong
시냅스 뇌질환 연구단
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Parallel processing of working memory and temporal information by distinct types of cortical projection neurons

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Title
Parallel processing of working memory and temporal information by distinct types of cortical projection neurons
Author(s)
Bae, Jung Won; Huijeong Jeong; Yoon, Young Ju; Chan Mee Bae; Lee, Hyeonsu; Paik, Se-Bum; Min Whan Jung
Publication Date
2021-07
Journal
NATURE COMMUNICATIONS, v.12, no.1
Publisher
NATURE RESEARCH
Abstract
© The Author(s) 2021 It is unclear how different types of cortical projection neurons work together to support diverse cortical functions. We examined the discharge characteristics and inactivation effects of intratelencephalic (IT) and pyramidal tract (PT) neurons-two major types of cortical excitatory neurons that project to cortical and subcortical structures, respectively-in the deep layer of the medial prefrontal cortex in mice performing a delayed response task. We found stronger target-dependent firing of IT than PT neurons during the delay period. We also found the inactivation of IT neurons, but not PT neurons, impairs behavioral performance. In contrast, PT neurons carry more temporal information than IT neurons during the delay period. Our results indicate a division of labor between IT and PT projection neurons in the prefrontal cortex for the maintenance of working memory and for tracking the passage of time, respectively. Intratelencephalic and pyramidal tract neurons are two major types of cortical excitatory neurons that project to cortical and subcortical structures. The authors show that in the prefrontal cortex the two populations have different roles for the maintenance of working memory and for tracking the passage of time.
URI
https://pr.ibs.re.kr/handle/8788114/10043
DOI
10.1038/s41467-021-24565-z
ISSN
2041-1723
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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