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뇌과학이미징연구단
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Injectable tissue prosthesis for instantaneous closed-loop rehabilitation

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dc.contributor.authorSubin Jin-
dc.contributor.authorHeewon Choi-
dc.contributor.authorDuhwan Seong-
dc.contributor.authorYou, Chang-Lim-
dc.contributor.authorKang, Jong-Sun-
dc.contributor.authorRho, Seunghyok-
dc.contributor.authorLee, Won Bo-
dc.contributor.authorDonghee Son-
dc.contributor.authorMikyung Shin-
dc.date.accessioned2023-11-16T22:00:19Z-
dc.date.available2023-11-16T22:00:19Z-
dc.date.created2023-11-13-
dc.date.issued2023-11-
dc.identifier.issn0028-0836-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/14156-
dc.description.abstractTo construct tissue-like prosthetic materials, soft electroactive hydrogels are the best candidate owing to their physiological mechanical modulus, low electrical resistance and bidirectional stimulating and recording capability of electrophysiological signals from biological tissues1,2. Nevertheless, until now, bioelectronic devices for such prostheses have been patch type, which cannot be applied onto rough, narrow or deep tissue surfaces3–5. Here we present an injectable tissue prosthesis with instantaneous bidirectional electrical conduction in the neuromuscular system. The soft and injectable prosthesis is composed of a biocompatible hydrogel with unique phenylborate-mediated multiple crosslinking, such as irreversible yet freely rearrangeable biphenyl bonds and reversible coordinate bonds with conductive gold nanoparticles formed in situ by cross-coupling. Closed-loop robot-assisted rehabilitation by injecting this prosthetic material is successfully demonstrated in the early stage of severe muscle injury in rats, and accelerated tissue repair is achieved in the later stage. © 2023, The Author(s), under exclusive licence to Springer Nature Limited.-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleInjectable tissue prosthesis for instantaneous closed-loop rehabilitation-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001169130500007-
dc.identifier.scopusid2-s2.0-85175731092-
dc.identifier.rimsid82104-
dc.contributor.affiliatedAuthorSubin Jin-
dc.contributor.affiliatedAuthorHeewon Choi-
dc.contributor.affiliatedAuthorDuhwan Seong-
dc.contributor.affiliatedAuthorDonghee Son-
dc.contributor.affiliatedAuthorMikyung Shin-
dc.identifier.doi10.1038/s41586-023-06628-x-
dc.identifier.bibliographicCitationNature, v.623, no.7985, pp.58 - 65-
dc.relation.isPartOfNature-
dc.citation.titleNature-
dc.citation.volume623-
dc.citation.number7985-
dc.citation.startPage58-
dc.citation.endPage65-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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