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유전체항상성연구단
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Active DNA damage eviction by HLTF stimulates nucleotide excision repair

DC Field Value Language
dc.contributor.authorvan Toorn, Marvin-
dc.contributor.authorTurkyilmaz, Yasemin-
dc.contributor.authorHan, Sueji-
dc.contributor.authorZhou, Di-
dc.contributor.authorHyun-Suk Kim-
dc.contributor.authorSalas-Armenteros, Irene-
dc.contributor.authorMihyun Kim-
dc.contributor.authorAkita, Masaki-
dc.contributor.authorWienholz, Franziska-
dc.contributor.authorRaams, Anja-
dc.contributor.authorEunjin Ryu-
dc.contributor.authorSukhyun Kang-
dc.contributor.authorTheil, Arjan F.-
dc.contributor.authorBezstarosti, Karel-
dc.contributor.authorTresini, Maria-
dc.contributor.authorGiglia-Mari, Giuseppina-
dc.contributor.authorDemmers, Jeroen A.-
dc.contributor.authorOrlando D. Schärer-
dc.contributor.authorChoi, Jun-Hyuk-
dc.contributor.authorVermeulen, Wim-
dc.contributor.authorMarteijn, Jurgen A.-
dc.date.accessioned2023-01-27T02:57:10Z-
dc.date.available2023-01-27T02:57:10Z-
dc.date.created2022-04-18-
dc.date.issued2022-04-
dc.identifier.issn1097-2765-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12948-
dc.description.abstract© 2022 Elsevier Inc.Nucleotide excision repair (NER) counteracts the onset of cancer and aging by removing helix-distorting DNA lesions via a “cut-and-patch”-type reaction. The regulatory mechanisms that drive NER through its successive damage recognition, verification, incision, and gap restoration reaction steps remain elusive. Here, we show that the RAD5-related translocase HLTF facilitates repair through active eviction of incised damaged DNA together with associated repair proteins. Our data show a dual-incision-dependent recruitment of HLTF to the NER incision complex, which is mediated by HLTF's HIRAN domain that binds 3′-OH single-stranded DNA ends. HLTF's translocase motor subsequently promotes the dissociation of the stably damage-bound incision complex together with the incised oligonucleotide, allowing for an efficient PCNA loading and initiation of repair synthesis. Our findings uncover HLTF as an important NER factor that actively evicts DNA damage, thereby providing additional quality control by coordinating the transition between the excision and DNA synthesis steps to safeguard genome integrity.-
dc.language영어-
dc.publisherCell Press-
dc.titleActive DNA damage eviction by HLTF stimulates nucleotide excision repair-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000787084900011-
dc.identifier.scopusid2-s2.0-85127515152-
dc.identifier.rimsid78009-
dc.contributor.affiliatedAuthorHyun-Suk Kim-
dc.contributor.affiliatedAuthorMihyun Kim-
dc.contributor.affiliatedAuthorEunjin Ryu-
dc.contributor.affiliatedAuthorSukhyun Kang-
dc.contributor.affiliatedAuthorOrlando D. Schärer-
dc.identifier.doi10.1016/j.molcel.2022.02.020-
dc.identifier.bibliographicCitationMolecular Cell, v.82, no.7, pp.1343 - 1358.e8-
dc.relation.isPartOfMolecular Cell-
dc.citation.titleMolecular Cell-
dc.citation.volume82-
dc.citation.number7-
dc.citation.startPage1343-
dc.citation.endPage1358.e8-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.subject.keywordPlusTRANSCRIPTION FACTOR HLTF-
dc.subject.keywordPlusCELL NUCLEAR ANTIGEN-
dc.subject.keywordPlusESCHERICHIA-COLI-
dc.subject.keywordPlusFORK REVERSAL-
dc.subject.keywordPlusPOLYMERASE-I-
dc.subject.keywordPlusHELICASE-II-
dc.subject.keywordPlusREPLICATION-
dc.subject.keywordPlusTFIIH-
dc.subject.keywordPlusRECOGNITION-
dc.subject.keywordPlusPROTEIN-
dc.subject.keywordAuthordamage eviction-
dc.subject.keywordAuthorDNA damage-
dc.subject.keywordAuthorgenome stability-
dc.subject.keywordAuthorHLTF-
dc.subject.keywordAuthornucleotide excision repair-
dc.subject.keywordAuthorpost-replication repair-
dc.subject.keywordAuthorrepair synthesis-
dc.subject.keywordAuthorTFIIH-
dc.subject.keywordAuthorUV damage response-
Appears in Collections:
Center for Genomic Integrity(유전체 항상성 연구단) > 1. Journal Papers (저널논문)
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