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첨단연성물질연구단
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Prediction of tumor metastasis via extracellular vesicles-treated platelet adhesion on a blood vessel chip

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dc.contributor.authorJunyoung Kim-
dc.contributor.authorVijaya Sunkara-
dc.contributor.authorJungmin Kim-
dc.contributor.authorJooyoung Ro-
dc.contributor.authorChi-Ju Kim-
dc.contributor.authorElizabeth Maria Clarissa-
dc.contributor.authorSung Wook Jung-
dc.contributor.authorHee Jin Lee-
dc.contributor.authorYoon-Kyoung Cho-
dc.date.accessioned2023-01-27T01:52:15Z-
dc.date.available2023-01-27T01:52:15Z-
dc.date.created2022-07-22-
dc.date.issued2022-07-
dc.identifier.issn1473-0197-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/12907-
dc.description.abstractIn preclinical and clinical studies, it has been demonstrated that tumor-educated platelets play a critical role in tumorigenesis, cancer development, and metastasis. Unlike the role of cancer-derived chemokines in platelet activation, the role of cancer-derived extracellular vesicles (EVs) has remained elusive. Here, we found that interleukin-8 (IL-8) in cancer-derived EVs contributed to platelet activation by increasing P-selectin expression and ligand affinity, resulting in increased platelet adhesion on the human vessel-mimicking microfluidic system. Furthermore, platelet adhesion levels on vessels treated with human plasma-derived EVs demonstrated good discrimination between breast cancer patients with metastasis and those without, with the area under the curve (AUC) value of 0.88. While EpCAM expression on EVs could detect the existence of a tumor (AUC = 0.89), it performed poorly in predicting metastasis (AUC = 0.42). We believe that these findings shed light on the role of the interaction between cancer-derived EVs and platelets in pre-metastatic niche formation and tumor metastasis, potentially leading to the development of platelet-tumor interaction-based novel diagnostic and therapeutic strategies. © 2022 The Royal Society of Chemistry-
dc.language영어-
dc.publisherRoyal Society of Chemistry-
dc.titlePrediction of tumor metastasis via extracellular vesicles-treated platelet adhesion on a blood vessel chip-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000817653500001-
dc.identifier.scopusid2-s2.0-85133572595-
dc.identifier.rimsid78547-
dc.contributor.affiliatedAuthorJunyoung Kim-
dc.contributor.affiliatedAuthorVijaya Sunkara-
dc.contributor.affiliatedAuthorJungmin Kim-
dc.contributor.affiliatedAuthorJooyoung Ro-
dc.contributor.affiliatedAuthorChi-Ju Kim-
dc.contributor.affiliatedAuthorYoon-Kyoung Cho-
dc.identifier.doi10.1039/d2lc00364c-
dc.identifier.bibliographicCitationLab on a Chip, v.22, no.14, pp.2726 - 2740-
dc.relation.isPartOfLab on a Chip-
dc.citation.titleLab on a Chip-
dc.citation.volume22-
dc.citation.number14-
dc.citation.startPage2726-
dc.citation.endPage2740-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaInstruments & Instrumentation-
dc.relation.journalWebOfScienceCategoryBiochemical Research Methods-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Analytical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryInstruments & Instrumentation-
dc.subject.keywordPlusTISSUE FACTOR-
dc.subject.keywordPlusCANCER GROWTH-
dc.subject.keywordPlusSHEAR-STRESS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusEXOSOMES-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusINTERLEUKIN-8-
dc.subject.keywordPlusAGGREGATION-
Appears in Collections:
Center for Soft and Living Matter(첨단연성물질 연구단) > 1. Journal Papers (저널논문)
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