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Lee, ChangJoon Justin
인지 및 사회성 연구단
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Reactive astrocyte nomenclature, definitions, and future directions

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Reactive astrocyte nomenclature, definitions, and future directions
Escartin, Carole; Galea, Elena; Lakatos, Andras; O'Callaghan, James P.; Petzold, Gabor C.; Serrano-Pozo, Alberto; Steinhauser, Christian; Volterra, Andrea; Carmignoto, Giorgio; Agarwal, Amit; Allen, Nicola J.; Araque, Alfonso; Barbeito, Luis; Barzilai, Ari; Bergles, Dwight E.; Bonvento, Gilles; Butt, Arthur M.; Chen, Wei-Ting; Cohen-Salmon, Martine; Cunningham, Colm; Deneen, Benjamin; De Strooper, Bart; Diaz-Castro, Blanca; Farina, Cinthia; Freeman, Marc; Gallo, Vittorio; Goldman, James E.; Goldman, Steven A.; Gotz, Magdalena; Gutierrez, Antonia; Haydon, Philip G.; Heiland, Dieter H.; Hol, Elly M.; Holt, Matthew G.; Iino, Masamitsu; Kastanenka, Ksenia V.; Kettenmann, Helmut; Khakh, Baljit S.; Koizumi, Schuichi; C. Justin Lee; Liddelow, Shane A.; MacVicar, Brian A.; Magistretti, Pierre; Messing, Albee; Mishra, Anusha; Molofsky, Anna V.; Murai, Keith K.; Norris, Christopher M.; Okada, Seiji; Oliet, Stephane H. R.; Oliveira, Joao F.; Panatier, Aude; Parpura, Vladimir; Pekna, Marcela; Pekny, Milos; Pellerin, Luc; Perea, Gertrudis; Perez-Nievas, Beatriz G.; Pfrieger, Frank W.; Poskanzer, Kira E.; Quintana, Francisco J.; Ransohoff, Richard M.; Riquelme-Perez, Miriam; Robel, Stefanie; Rose, Christine R.; Rothstein, Jeffrey D.; Rouach, Nathalie; Rowitch, David H.; Semyanov, Alexey; Sirko, Swetlana; Sontheimer, Harald; Swanson, Raymond A.; Vitorica, Javier; Wanner, Ina-Beate; Wood, Levi B.; Wu, Jiaqian; Zheng, Binhai; Zimmer, Eduardo R.; Zorec, Robert; Sofroniew, Michael V.; Verkhratsky, Alexei
Publication Date
NATURE NEUROSCIENCE, v.24, pp.312 - 325
Reactive astrocytes are astrocytes undergoing morphological, molecular, and functional remodeling in response to injury, disease, or infection of the CNS. Although this remodeling was first described over a century ago, uncertainties and controversies remain regarding the contribution of reactive astrocytes to CNS diseases, repair, and aging. It is also unclear whether fixed categories of reactive astrocytes exist and, if so, how to identify them. We point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic-vs-neuroprotective or A1-vs-A2. We advocate, instead, that research on reactive astrocytes include assessment of multiple molecular and functional parameters-preferably in vivo-plus multivariate statistics and determination of impact on pathological hallmarks in relevant models. These guidelines may spur the discovery of astrocyte-based biomarkers as well as astrocyte-targeting therapies that abrogate detrimental actions of reactive astrocytes, potentiate their neuro- and glioprotective actions, and restore or augment their homeostatic, modulatory, and defensive functions. Good-bad binary classifications fail to describe reactive astrocytes in CNS disorders. Here, 81 researchers reach consensus on widespread misconceptions and provide definitions and recommendations for future research on reactive astrocytes.
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Center for Cognition and Sociality(인지 및 사회성 연구단) > 1. Journal Papers (저널논문)
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