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나노의학 연구단
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Roles of the CIC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. eleagns

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Title
Roles of the CIC chloride channel CLH-1 in food-associated salt chemotaxis behavior of C. eleagns
Author(s)
Chanhyun Park; Yuki Sakurai; Hirofumi Sato; Shinji Kanda; Yuichi Iino; Hirofumi Kunitomo
Publication Date
2021-01
Journal
ELIFE, v.10, pp.1 - 27
Publisher
ELIFE SCIENCES PUBLICATIONS LTD
Abstract
The ability of animals to process dynamic sensory information facilitates foraging in an ever-changing environment. However, molecular and neural mechanisms underlying such ability remain elusive. The CIC anion channels/transporters play a pivotal role in cellular ion homeostasis across all phyla. Here, we find a CIC chloride channel is involved in salt concentration chemotaxis of Caenorhabditis elegans. Genetic screening identified two altered-function mutations of clh-1 that disrupt experience-dependent salt chemotaxis. Using genetically encoded fluorescent sensors, we demonstrate that CLH-1 contributes to regulation of intracellular anion and calcium dynamics of salt-sensing neuron, ASER. The mutant CLH-1 reduced responsiveness of ASER to salt stimuli in terms of both temporal resolution and intensity, which disrupted navigation strategies for approaching preferred salt concentrations. Furthermore, other CIC genes appeared to act redundantly in salt chemotaxis. These findings provide insights into the regulatory mechanism of neuronal responsivity by CICs that contribute to modulation of navigation behavior.
URI
https://pr.ibs.re.kr/handle/8788114/9454
DOI
10.7554/eLife.55701
ISSN
2050-084X
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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