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High-resolution T-1 MRI via renally clearable dextran nanoparticles with an iron oxide shell

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dc.contributor.authorTae-Hyun Shin-
dc.contributor.authorPan Ki Kim-
dc.contributor.authorSunghwi Kang-
dc.contributor.authorJiyong Cheong-
dc.contributor.authorSoojin Kim-
dc.contributor.authorYongjun Lim-
dc.contributor.authorWookjin Shin-
dc.contributor.authorJoon-Yong Jung-
dc.contributor.authorJungsu D. Lah-
dc.contributor.authorByoung Wook Choi-
dc.contributor.authorJinwoo Cheon-
dc.date.accessioned2021-04-07T06:30:16Z-
dc.date.accessioned2021-04-07T06:30:16Z-
dc.date.available2021-04-07T06:30:16Z-
dc.date.available2021-04-07T06:30:16Z-
dc.date.created2021-03-24-
dc.date.issued2021-03-
dc.identifier.issn2157-846X-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9325-
dc.description.abstractContrast agents for magnetic resonance imaging (MRI) improve anatomical visualizations. However, owing to poor image resolution in whole-body MRI, resolving fine structures is challenging. Here, we report that a nanoparticle with a polysaccharide supramolecular core and a shell of amorphous-like hydrous ferric oxide generating strong T-1 MRI contrast (with a relaxivity coefficient ratio of similar to 1.2) facilitates the imaging, at resolutions of the order of a few hundred micrometres, of cerebral, coronary and peripheral microvessels in rodents and of lower-extremity vessels in rabbits. The nanoparticle can be synthesized at room temperature in aqueous solution and in the absence of surfactants, has blood circulation and renal clearance profiles that prevent opsonization, and leads to better imaging performance than Dotarem (gadoterate meglumine), a clinically approved gadolinium-based MRI contrast agent. The nanoparticle's biocompatibility and imaging performance may prove advantageous in a broad range of preclinical and clinical applications of MRI.-
dc.language영어-
dc.publisherNATURE RESEARCH-
dc.titleHigh-resolution T-1 MRI via renally clearable dextran nanoparticles with an iron oxide shell-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000626376300001-
dc.identifier.scopusid2-s2.0-85102360696-
dc.identifier.rimsid75152-
dc.contributor.affiliatedAuthorTae-Hyun Shin-
dc.contributor.affiliatedAuthorPan Ki Kim-
dc.contributor.affiliatedAuthorSunghwi Kang-
dc.contributor.affiliatedAuthorJiyong Cheong-
dc.contributor.affiliatedAuthorSoojin Kim-
dc.contributor.affiliatedAuthorYongjun Lim-
dc.contributor.affiliatedAuthorWookjin Shin-
dc.contributor.affiliatedAuthorJoon-Yong Jung-
dc.contributor.affiliatedAuthorJungsu D. Lah-
dc.contributor.affiliatedAuthorJinwoo Cheon-
dc.identifier.doi10.1038/s41551-021-00687-z-
dc.identifier.bibliographicCitationNATURE BIOMEDICAL ENGINEERING, v.5, no.3, pp.252 - 263-
dc.relation.isPartOfNATURE BIOMEDICAL ENGINEERING-
dc.citation.titleNATURE BIOMEDICAL ENGINEERING-
dc.citation.volume5-
dc.citation.number3-
dc.citation.startPage252-
dc.citation.endPage263-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaEngineering-
dc.relation.journalWebOfScienceCategoryEngineering, Biomedical-
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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