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High-resolution T-1 MRI via renally clearable dextran nanoparticles with an iron oxide shell

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Title
High-resolution T-1 MRI via renally clearable dextran nanoparticles with an iron oxide shell
Author(s)
Tae-Hyun Shin; Pan Ki Kim; Sunghwi Kang; Jiyong Cheong; Soojin Kim; Yongjun Lim; Wookjin Shin; Joon-Yong Jung; Jungsu D. Lah; Byoung Wook Choi; Jinwoo Cheon
Publication Date
2021-03
Journal
NATURE BIOMEDICAL ENGINEERING, v.5, no.3, pp.252 - 263
Publisher
NATURE RESEARCH
Abstract
Contrast agents for magnetic resonance imaging (MRI) improve anatomical visualizations. However, owing to poor image resolution in whole-body MRI, resolving fine structures is challenging. Here, we report that a nanoparticle with a polysaccharide supramolecular core and a shell of amorphous-like hydrous ferric oxide generating strong T-1 MRI contrast (with a relaxivity coefficient ratio of similar to 1.2) facilitates the imaging, at resolutions of the order of a few hundred micrometres, of cerebral, coronary and peripheral microvessels in rodents and of lower-extremity vessels in rabbits. The nanoparticle can be synthesized at room temperature in aqueous solution and in the absence of surfactants, has blood circulation and renal clearance profiles that prevent opsonization, and leads to better imaging performance than Dotarem (gadoterate meglumine), a clinically approved gadolinium-based MRI contrast agent. The nanoparticle's biocompatibility and imaging performance may prove advantageous in a broad range of preclinical and clinical applications of MRI.
URI
https://pr.ibs.re.kr/handle/8788114/9325
DOI
10.1038/s41551-021-00687-z
ISSN
2157-846X
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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