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Design and material for a patternable polysiloxane acrylate-based penetrating intracortical neural probe

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Title
Design and material for a patternable polysiloxane acrylate-based penetrating intracortical neural probe
Author(s)
Jung, Woojin; Heo, Chaejeong; Kim, Jong Uk; Jeong, Chanho; Ryu, Hyewon; Park, Byeonghak; Suh, Minah; Kim, Tae-il
Publication Date
2021-03
Journal
Journal of Micromechanics and Microengineering, v.31, no.3
Publisher
Institute of Physics Publishing
Abstract
Despite significant demand for penetrating intracortical neural probes (PINPs), challenges remain regarding their biocompatibility and stability due to the mechanical mismatch between brain tissue and PINPs. Here, we propose a promising UV patternable polymeric material for PINPs and a design criterion for optimizing the geometry of polymeric PINPs. UV-curable polysiloxane acrylate (PSA) shows remarkably low cytotoxicity in vitro, comparable to that of polyimide. Real-time two-photon imaging of CX3CR1-gfp-Tg mice reveals that a PSA microneedle shows a markedly low immune-responsive effect. The photo-patternability and modulus-tunability of PSA provide effective design capability, even for hierarchical structures. Also, we found a design criterion suggesting minimized scar that can penetrate the tissue surface, reducing both iatrogenic injury and mechanical mismatch while simultaneously dampening tissue micromotion. This damping behaviour of polymeric PINPS was shown by both experimental methods and finite element method simulation. Finally, we fabricated gold electrodes on PSA microneedles and successfully recorded local field potentials during seizure activity.
URI
https://pr.ibs.re.kr/handle/8788114/9174
DOI
10.1088/1361-6439/abdb78
ISSN
0960-1317
Appears in Collections:
Center for Integrated Nanostructure Physics(나노구조물리 연구단) > 1. Journal Papers (저널논문)
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > 1. Journal Papers (저널논문)
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