BROWSE

Related Scientist

jang,seil's photo.

jang,seil
시냅스뇌질환연구단
more info

ITEM VIEW & DOWNLOAD

Clmp Regulates AMPA and Kainate Receptor Responses in the Neonatal Hippocampal CA3 and Kainate Seizure Susceptibility in Mice

DC Field Value Language
dc.contributor.authorSeil Jang-
dc.contributor.authorYang, Esther-
dc.contributor.authorKim, Doyoun-
dc.contributor.authorKim, Hyun-
dc.contributor.authorEunjoon Kim-
dc.date.accessioned2021-01-26T02:30:05Z-
dc.date.accessioned2021-01-26T02:30:05Z-
dc.date.available2021-01-26T02:30:05Z-
dc.date.available2021-01-26T02:30:05Z-
dc.date.created2021-01-22-
dc.date.issued2020-12-
dc.identifier.issn1663-3563-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/9104-
dc.description.abstractSynaptic adhesion molecules regulate synapse development through trans-synaptic adhesion and assembly of diverse synaptic proteins. Many synaptic adhesion molecules positively regulate synapse development; some, however, exert negative regulation, although such cases are relatively rare. In addition, synaptic adhesion molecules regulate the amplitude of post-synaptic receptor responses, but whether adhesion molecules can regulate the kinetic properties of post-synaptic receptors remains unclear. Here we report that amp, a homophilic adhesion molecule of the Ig domain superfamily that is abundantly expressed in the brain, reaches peak expression at a neonatal stage (week 1) and associates with subunits of AMPA receptors (AMPARs) and kainate receptors (KARs). Clmp deletion in mice increased the frequency and amplitude of AMPAR-mediated miniature excitatory post-synaptic currents (mEPSCs) and the frequency, amplitude, and decay time constant of KAR-mediated mEPSCs in hippocampal CA3 neurons. Cimp deletion had minimal impacts on evoked excitatory synaptic currents at mossy fiber-CA3 synapses but increased extrasynaptic KAR, but not AMPAR, currents, suggesting that amp distinctly inhibits AMPAR and KAR responses. Behaviorally, Cimp deletion enhanced novel object recognition and susceptibility to kainate-induced seizures, without affecting contextual or auditory cued fear conditioning or pattern completion-based contextual fear conditioning. These results suggest that amp negatively regulates hippocampal excitatory synapse development and AMPAR and KAR responses in the neonatal hippocampal CA3 as well as object recognition and kainate seizure susceptibility in mice.-
dc.description.uri1-
dc.language영어-
dc.publisherFrontiers Media S.A.-
dc.subjectAMPA receptors-
dc.subjecthippocampus-
dc.subjectkainate receptors-
dc.subjectlearning and memory-
dc.subjectNMDA receptors-
dc.subjectseizure-
dc.subjectsynaptic adhesion molecule-
dc.subjectsynaptic transmission-
dc.titleClmp Regulates AMPA and Kainate Receptor Responses in the Neonatal Hippocampal CA3 and Kainate Seizure Susceptibility in Mice-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000603463800001-
dc.identifier.scopusid2-s2.0-85098767840-
dc.identifier.rimsid74323-
dc.contributor.affiliatedAuthorSeil Jang-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.doi10.3389/fnsyn.2020.567075-
dc.identifier.bibliographicCitationFrontiers in Synaptic Neuroscience, v.12, pp.1 - 19-
dc.citation.titleFrontiers in Synaptic Neuroscience-
dc.citation.volume12-
dc.citation.startPage1-
dc.citation.endPage19-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusSYNAPTIC ADHESION MOLECULES-
dc.subject.keywordPlusLONG-TERM POTENTIATION-
dc.subject.keywordPlusPROTEIN-STRUCTURE-
dc.subject.keywordPlusMEMORY CONSOLIDATION-
dc.subject.keywordPlusNMDA RECEPTORS-
dc.subject.keywordPlusKAINIC ACID-
dc.subject.keywordPlusTRANSMISSION-
dc.subject.keywordPlusSUBUNIT-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusPLASTICITY-
dc.subject.keywordAuthorsynaptic adhesion molecule-
dc.subject.keywordAuthorsynaptic transmission-
dc.subject.keywordAuthorAMPA receptors-
dc.subject.keywordAuthorkainate receptors-
dc.subject.keywordAuthorNMDA receptors-
dc.subject.keywordAuthorhippocampus-
dc.subject.keywordAuthorlearning and memory-
dc.subject.keywordAuthorseizure-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse