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Smart, soft contact lens for wireless immunosensing of cortisol

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Title
Smart, soft contact lens for wireless immunosensing of cortisol
Author(s)
Minjae Ku; Joohee Kim; Jong-Eun Won; Wonkyu Kang; Young-Geun Park; Jihun Park; Jae-Hyun Lee; Jinwoo Cheon; Hyun Ho Lee; Jang-Ung Park
Subject
LABEL-FREE DETECTION, ; DNA HYBRIDIZATION, ; STRESS, ; GRAPHENE, ; BIOMARKER, ; SENSORS, ; HAIR
Publication Date
2020-07
Journal
Science Advances, v.6, no.28, pp.eabb2891
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Abstract
Copyright © 2020 The Authors, some rights reserved.Despite various approaches to immunoassay and chromatography for monitoring cortisol concentrations, conventional methods require bulky external equipment, which limits their use as mobile health care systems. Here, we describe a human pilot trial of a soft, smart contact lens for real-Time detection of the cortisol concentration in tears using a smartphone. A cortisol sensor formed using a graphene field-effect transistor can measure cortisol concentration with a detection limit of 10 pg/ml, which is low enough to detect the cortisol concentration in human tears. In addition, this soft contact lens only requires the integration of this cortisol sensor with transparent antennas and wireless communication circuits to make a smartphone the only device needed to operate the lens remotely without obstructing the wearer's view. Furthermore, in vivo tests using live rabbits and the human pilot experiment confirmed the good biocompatibility and reliability of this lens as a noninvasive, mobile health care solution
URI
https://pr.ibs.re.kr/handle/8788114/7773
DOI
10.1126/sciadv.abb2891
ISSN
2375-2548
Appears in Collections:
Center for Nanomedicine (나노의학 연구단) > 1. Journal Papers (저널논문)
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