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Park, Ji Hwan
식물 노화·수명 연구단
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Dynamic transcriptome analysis unveils key proresolving factors of chronic inflammatory arthritis

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dc.contributor.authorJin-Sun Kong-
dc.contributor.authorJi-Hwan Park-
dc.contributor.authorSeung-Ah Yoo-
dc.contributor.authorKi-Myo Kim-
dc.contributor.authorYeung-Jin Bae-
dc.contributor.authorYune-Jung Park-
dc.contributor.authorChul-Soo Cho-
dc.contributor.authorDaehee Hwang-
dc.contributor.authorWan-Uk Kim-
dc.date.accessioned2020-12-22T02:47:30Z-
dc.date.accessioned2020-12-22T02:47:30Z-
dc.date.available2020-12-22T02:47:30Z-
dc.date.available2020-12-22T02:47:30Z-
dc.date.created2020-11-18-
dc.date.issued2020-08-
dc.identifier.issn0021-9738-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7672-
dc.description.abstract© 2020, American Society for Clinical Investigation. Despite recent advances in understanding chronic inflammation remission, global analyses have not been explored to systematically discover genes or pathways underlying the resolution dynamics of chronic inflammatory diseases. Here, we performed time-course gene expression profiling of mouse synovial tissues along progression and resolution of collagen-induced arthritis (CIA) and identified genes associated with inflammation resolution. Through network analysis of these genes, we predicted 3 key secretory factors responsible for the resolution of CIA: Itgb1, Rps3, and Ywhaz. These factors were predominantly expressed by Tregs and antiinflammatory M2 macrophages, suppressing production of proinflammatory cytokines. In particular, Ywhaz was elevated in the sera of mice with arthritis resolution and in the urine of rheumatoid arthritis (RA) patients with good therapeutic responses. Moreover, adenovirus-mediated transfer of the Ywhaz gene to the affected joints substantially inhibited arthritis progression in mice with CIA and suppressed expression of proinflammatory cytokines in joint tissues, lymph nodes, and spleens, suggesting Ywhaz is an excellent target for RA therapy. Therefore, our comprehensive analysis of dynamic synovial transcriptomes provides previously unidentified antiarthritic genes, Itgb1, Rps3, and Ywhaz, which can serve as molecular markers to predict disease remission, as well as therapeutic targets for chronic inflammatory arthritis-
dc.description.uri1-
dc.language영어-
dc.publisherAMER SOC CLINICAL INVESTIGATION INC-
dc.subjectCOLLAGEN-INDUCED ARTHRITIS-
dc.subjectRHEUMATOID-ARTHRITIS-
dc.subjectRESOLUTION-
dc.subjectMACROPHAGES-
dc.subjectAUTOIMMUNE-
dc.subjectCELLS-
dc.subjectACTIVATION-
dc.subjectREMISSION-
dc.subjectPROTEINS-
dc.subjectMICE-
dc.titleDynamic transcriptome analysis unveils key proresolving factors of chronic inflammatory arthritis-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000579396700009-
dc.identifier.scopusid2-s2.0-85086023325-
dc.identifier.rimsid73735-
dc.contributor.affiliatedAuthorJi-Hwan Park-
dc.contributor.affiliatedAuthorDaehee Hwang-
dc.identifier.doi10.1172/JCI126866-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL INVESTIGATION, v.130, no.8, pp.3974 - 3986-
dc.citation.titleJOURNAL OF CLINICAL INVESTIGATION-
dc.citation.volume130-
dc.citation.number8-
dc.citation.startPage3974-
dc.citation.endPage3986-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusCOLLAGEN-INDUCED ARTHRITIS-
dc.subject.keywordPlusRHEUMATOID-ARTHRITIS-
dc.subject.keywordPlusRESOLUTION-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusAUTOIMMUNE-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusREMISSION-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusMICE-
Appears in Collections:
Center for Plant Aging Research (식물 노화·수명 연구단) > 1. Journal Papers (저널논문)
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