BROWSE

Related Scientist

SYNAPSE's photo.

SYNAPSE
시냅스 뇌질환 연구단
more info

ITEM VIEW & DOWNLOAD

Spatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways

DC Field Value Language
dc.contributor.authorJung Hwan Shin-
dc.contributor.authorMin Song-
dc.contributor.authorSe-Bum Paik-
dc.contributor.authorMin Whan Jung-
dc.date.accessioned2020-12-22T02:30:59Z-
dc.date.accessioned2020-12-22T02:30:59Z-
dc.date.available2020-12-22T02:30:59Z-
dc.date.available2020-12-22T02:30:59Z-
dc.date.created2020-11-18-
dc.date.issued2020-10-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7576-
dc.description.abstract© 2020 National Academy of Sciences. To obtain insights into striatal neural processes underlying reward-based learning and movement control, we examined spatial organizations of striatal neurons related to movement and reward-based learning. For this, we recorded the activity of direct- and indirect-pathway neurons (D1 and A2a receptor-expressing neurons, respectively) in mice engaged in probabilistic classical conditioning and open-field free exploration. We found broadly organized functional clusters of striatal neurons in the direct as well as indirect pathways for both movement- and reward-related variables. Functional clusters for different variables were partially overlapping in both pathways, but the overlap between outcome- and value-related functional clusters was greater in the indirect than direct pathway. Also, value-related spatial clusters were progressively refined during classical conditioning. Our study shows the broad and learning-dependent spatial organization of functional clusters of dorsal striatal neurons in the direct and indirect pathways. These findings further argue against the classic model of the basal ganglia and support the importance of spatiotemporal patterns of striatal neuronal ensemble activity in the control of behavior-
dc.description.uri1-
dc.language영어-
dc.publisherNATL ACAD SCIENCES-
dc.titleSpatial organization of functional clusters representing reward and movement information in the striatal direct and indirect pathways-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000582743300059-
dc.identifier.scopusid2-s2.0-85094869781-
dc.identifier.rimsid73691-
dc.contributor.affiliatedAuthorJung Hwan Shin-
dc.contributor.affiliatedAuthorMin Whan Jung-
dc.identifier.doi10.1073/pnas.2010361117-
dc.identifier.bibliographicCitationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.117, no.43, pp.27004 - 27015-
dc.citation.titlePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.citation.volume117-
dc.citation.number43-
dc.citation.startPage27004-
dc.citation.endPage27015-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusBASAL GANGLIA-
dc.subject.keywordPlusOPTOGENETIC CONTROL-
dc.subject.keywordPlusDORSAL STRIATUM-
dc.subject.keywordPlusNEURONS-
dc.subject.keywordPlusREINFORCEMENT-
dc.subject.keywordPlusROLES-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusMODELS-
dc.subject.keywordPlusENCODE-
dc.subject.keywordAuthorstriatum-
dc.subject.keywordAuthorcalcium imaging-
dc.subject.keywordAuthorprobabilistic classical conditioning-
dc.subject.keywordAuthorvalue-
dc.subject.keywordAuthorreward-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse