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KIM, Namhoon
분자활성 촉매반응 연구단
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C2-Selective C-H Methylation of Heterocyclic N-Oxides with Sulfonium Ylides

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dc.contributor.authorWon An-
dc.contributor.authorSu Bin Choi-
dc.contributor.authorNamhoon Kim-
dc.contributor.authorNa Yean Kwon-
dc.contributor.authorPrithwish Ghosh-
dc.contributor.authorSang Hoon Han-
dc.contributor.authorNeeraj Kumar Mishra-
dc.contributor.authorSangil Han-
dc.contributor.authorSungwoo Hong-
dc.contributor.authorIn Su Kim-
dc.date.accessioned2020-12-22T02:22:59Z-
dc.date.accessioned2020-12-22T02:22:59Z-
dc.date.available2020-12-22T02:22:59Z-
dc.date.available2020-12-22T02:22:59Z-
dc.date.created2020-12-09-
dc.date.issued2020-11-20-
dc.identifier.issn1523-7060-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/7534-
dc.description.abstractA redox-neutral C2-selective methylation of heterocyclic N-oxides with sulfonium ylides is described herein. This report presents unprecedented findings for the utility of sulfonium ylides as the methylation source of N-heterocycles beyond the Corey-Chaykovsky reaction. Intriguingly, pyrrolidine plays a significant role in minimizing the reductive C2-methylation process. This method is characterized by its mild conditions, simplicity, and excellent site selectivity. The applicability of the developed protocol is showcased by the late-stage methylation and sequential transformations of complex drug molecules.-
dc.description.uri1-
dc.language영어-
dc.publisherAMER CHEMICAL SOC-
dc.subjectCrotonic Acid Derivative-
dc.subjectEpoxidation-
dc.subjectDimethylsulfoxonium Methylide-
dc.titleC2-Selective C-H Methylation of Heterocyclic N-Oxides with Sulfonium Ylides-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000592988800049-
dc.identifier.scopusid2-s2.0-85096508601-
dc.identifier.rimsid73964-
dc.contributor.affiliatedAuthorNamhoon Kim-
dc.contributor.affiliatedAuthorSungwoo Hong-
dc.identifier.doi10.1021/acs.orglett.0c03403-
dc.identifier.bibliographicCitationORGANIC LETTERS, v.22, no.22, pp.9004 - 9009-
dc.citation.titleORGANIC LETTERS-
dc.citation.volume22-
dc.citation.number22-
dc.citation.startPage9004-
dc.citation.endPage9009-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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