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Integration of locomotion and auditory signals in the mouse inferior colliculus

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Title
Integration of locomotion and auditory signals in the mouse inferior colliculus
Author(s)
Yoonsun Yang; Joonyeol Lee; Gunsoo Kim
Publication Date
2020-01
Journal
ELIFE, v.9, no., pp.e52228 -
Publisher
ELIFE SCIENCES PUBLICATIONS LTD
Abstract
© Yang et al.The inferior colliculus (IC) is the major midbrain auditory integration center, where virtually all ascending auditory inputs converge. Although the IC has been extensively studied for sound processing, little is known about the neural activity of the IC in moving subjects, as frequently happens in natural hearing conditions. Here, by recording neural activity in walking mice, we show that the activity of IC neurons is strongly modulated by locomotion, even in the absence of sound stimuli. Similar modulation was also found in hearing-impaired mice, demonstrating that IC neurons receive non-auditory, locomotion-related neural signals. Sound-evoked activity was attenuated during locomotion, and this attenuation increased frequency selectivity across the neuronal population, while maintaining preferred frequencies. Our results suggest that during behavior, integrating movement-related and auditory information is an essential aspect of sound processing in the IC
URI
https://pr.ibs.re.kr/handle/8788114/7263
ISSN
2050-084X
Appears in Collections:
Center for Neuroscience Imaging Research (뇌과학 이미징 연구단) > Journal Papers (저널논문)
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