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Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model

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Title
Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model
Author(s)
Choi, EJ; Hyuek Jong Lee; Kim, WJ; Han, KI; Iwasa, M; Kobayashi, K; Debnath, T; Tang, YJ; Kwak, YS; Yoon, JH; Kim, EK
Publication Date
2019-02
Journal
PLOS ONE, v.14, no.2, pp.e0210854 -
Publisher
PUBLIC LIBRARY SCIENCE
Abstract
Recent studies have demonstrated the immunomodulatory effects of heat-killed lactic acid bacteria. The aim of this study was to evaluate the protective effect of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on a model of inflammatory bowel disease (IBD). A total of 28 female NC/Nga mice were divided into 4 treatment groups. Controls were fed a normal commercial diet. In the experimental groups, colitis was induced by rectal administration of dinitrobenzene sulfonic acid. Two groups were orally administered 2 and 17 mg/kg EF2001, respectively. EF-2001 treatment decreased the expression of several cytokines, including cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS), interferon (IFN)-gamma, interleukin (IL)-1 beta, and IL-6 in inflamed colon compared to the DNBS alone group. In addition, EF-2001 suppressed DNBS-induced colonic tissue destruction. Therefore, this study strongly suggests that EF-2001 could alleviate the inflammation associated with mouse IBD. © 2019 Choi et al.
URI
https://pr.ibs.re.kr/handle/8788114/6943
ISSN
1932-6203
Appears in Collections:
Center for Vascular Research(혈관 연구단) > Journal Papers (저널논문)
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