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Albizzia julibrissin suppresses testosterone-induced benign prostatic hyperplasia by regulating 5α-reductase type 2 – androgen receptor pathway

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Title
Albizzia julibrissin suppresses testosterone-induced benign prostatic hyperplasia by regulating 5α-reductase type 2 – androgen receptor pathway
Author(s)
Hong G.-L.; Hyun-Tae Kim; Park S.-R.; Lee N.-H.; Ryu K.-A.; Kim T.-W.; Song G.-Y.; Jung J.-Y.
Publication Date
2019-09
Journal
Natural Product Sciences, v.25, no.3, pp.200 - 207
Publisher
Korean Society of Pharmacognosy
Abstract
© 2019, Korean Society of Pharmacognosy. All rights reserved.Albizzia julibrissin (AJ) is an herbal medicine that shows low toxicity, promotes promoting blood circulation and mitigates the inflammation and has mild side effects. Benign prostate hyperplasia (BPH) is one of the most common diseases that occurs in older males and often results in lower urinary tract symptoms. This study was conducted to evaluate the protective effect of AJ against BPH using LNCaP cells and Sprague Dawley rats treated with testosterone. Treatment with AJ extract reduced the expression of androgen receptor (AR) and prostate-specific antigen (PSA) in vitro. In vivo, rats were divided into 6 groups: 1 (Normal Control); 2 (Testosterone propionate (TP) alone); 3 (TP + finasteride); 4 (TP + AJ 10 mg/kg); 5 (TP + AJ 50 mg/kg); 6 (TP + AJ 300 mg/kg). The groups treated with AJ showed reduced the relative prostate weights and BPH-related proteins were altered, with decreased AR, PSA and proliferating cell nuclear antigen (PCNA) observed by western blot. Histopathological analysis revealed the therapeutic effect of AJ, with a decreased thickness of epithelial cells and reduced level of PCNA and 5α-reductase type 2. These results suggest that AJ extract could ameliorate testosterone-induced benign prostatic hyperplasia
URI
https://pr.ibs.re.kr/handle/8788114/6876
ISSN
1226-3907
Appears in Collections:
Center for Vascular Research(혈관 연구단) > Journal Papers (저널논문)
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