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시냅스 뇌질환 연구단
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Role of the hippocampal CA1 region in incremental value learning

DC Field Value Language
dc.contributor.authorYeongseok Jeong-
dc.contributor.authorNamjung Huh-
dc.contributor.authorJoonyeup Lee-
dc.contributor.authorInjae Yun-
dc.contributor.authorJong Won Lee-
dc.contributor.authorInah Lee-
dc.contributor.authorMin Whan Jung-
dc.date.available2019-02-12T11:03:14Z-
dc.date.created2018-07-23-
dc.date.issued2018-06-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/5562-
dc.description.abstractIt is generally believed that the hippocampus plays a crucial role in declarative memory-remembering facts and events-but not in gradual stimulus-response association or incremental value learning. Based on the finding that CA1 conveys strong value signals during dynamic foraging, we investigated the possibility that the hippocampus contributes to incremental value learning. Specifically, we examined effects of inactivating different subregions of the dorsal hippocampus on behavioral performance of mice performing a dynamic foraging task in a modified T-maze. A reinforcement learning model-based analysis indicated that inactivation of CA1, but not dentate gyrus, CA3, or CA2, impaired trial-by-trial updating of chosen value without affecting value-dependent action selection. As a result, it took longer for CA1-inactivated mice to bias their choices toward the higher-reward-probability target after changes in reward probability. Our results indicate, contrary to the traditional view, that the hippocampus, especially CA1, might contribute to incremental value learning under certain circumstances. © 2018 The Author(s)-
dc.languageENG-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleRole of the hippocampal CA1 region in incremental value learning-
dc.typeArticle-
dc.type.rimsA-
dc.identifier.wosid000436789500057-
dc.identifier.scopusid2-s2.0-85049300647-
dc.contributor.affiliatedAuthorNamjung Huh-
dc.contributor.affiliatedAuthorJoonyeup Lee-
dc.contributor.affiliatedAuthorJong Won Lee-
dc.contributor.affiliatedAuthorMin Whan Jung-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.8, no., pp.9870 --
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > Journal Papers (저널논문)
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