CX3CR1+ macrophages and CD8+ T cells control intestinal IgA production

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Title
CX3CR1+ macrophages and CD8+ T cells control intestinal IgA production
Author(s)
Young-In Kim; Joo-Hye Song; Hyun-Jeong Ko; Mi-Na Kweon; chang-Yuil Kang; Hans-Christian Reinecker; Sun-Young Chang
Publication Date
2018-08
Journal
JOURNAL OF IMMUNOLOGY, v.201, no.4, pp.1287 - 1294
Publisher
AMER ASSOC IMMUNOLOGISTS
Abstract
Secretory IgA is a key host defense mechanism that controls the intestinal microbiota. We investigated the role of CD11c+CX3CR1+CD64+ macrophages in IgA production in the intestine. Intestinal CX3CR1+ macrophages directly induced IgA secretion by B cells. Ag delivery to lamina propria (LP) CX3CR1+ macrophages specifically induced intestinal IgA production. The induction of IgA by CX3CR1+ macrophages required BAFF, a proliferation-inducing ligand, and TNF-a, but was surprisingly independent of TLR-mediated microbial recognition and retinoic acid signaling. IgA secretion by CX3CR1+ macrophages was enhanced by LP CD8+ T cells through the secretion of IL-9 and IL-13. CX3CR1+ macrophages and CD8+ T cells induced IgA production by B cells independently of mesenteric lymph nodes and Peyer patches. Our data reveal a previously unrecognized cellular circuitry in which LP CX3CR1+ macrophages, B cells, and CD8+ T cells coordinate the protective Ig secretion in the small intestine upon peripheral Ag delivery. © Copyright 2018 by The American Association of Immunologists, Inc
URI
https://pr.ibs.re.kr/handle/8788114/5215
ISSN
0022-1767
Appears in Collections:
Center for Cardiovascular Research(혈관 연구단) > Journal Papers (저널논문)
Files in This Item:
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