Synthesis and Characterization of Anguibactin To Reveal Its Competence To Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii

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Title
Synthesis and Characterization of Anguibactin To Reveal Its Competence To Function as a Thermally Stable Surrogate Siderophore for a Gram-Negative Pathogen, Acinetobacter baumannii
Author(s)
Haeun Lee; Woon Young Song; Minju Kim; Min Wook Lee; Soojeung Kim; Ye Song Park; Kyungwon Kwak; Mam Hwan Oh; Hak Joong Kim
Publication Date
2018-10
Journal
ORGANIC LETTERS, v.20, no.20, pp.6476 - 6479
Publisher
AMER CHEMICAL SOC
Abstract
Total synthesis of anguibactin was accomplished for the first time, and the following biochemical characterizations allowed for the determination of its Fe(III) binding mode as well as the demonstration of its iron delivery capability for Acinetobacter baumannii. These properties, in addition to the thermal stability over acinetobactin, render anguibactin as a competent surrogate siderophore that can be useful for the future development of a siderophore-based antibiotic delivery system against A. baumannii. © 2018 American Chemical Society.
URI
https://pr.ibs.re.kr/handle/8788114/5109
ISSN
1523-7060
Appears in Collections:
Center for Molecular Spectroscopy and Dynamics(분자 분광학 및 동력학 연구단) > Journal Papers (저널논문)
Files in This Item:
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