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분자활성촉매반응연구단
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Enhanced Fluorescence Turn-on Imaging of Hypochlorous Acid in Living Immune and Cancer Cells

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dc.contributor.authorSandip V. Mulay-
dc.contributor.authorMinsuk Choi-
dc.contributor.authorYoon Jeong Jang-
dc.contributor.authorYoungsam Kim-
dc.contributor.authorSangyong Jon-
dc.contributor.authorDavid G. Churchill-
dc.date.available2018-07-18T02:09:37Z-
dc.date.created2018-03-15-
dc.date.issued2016-07-
dc.identifier.issn0947-6539-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/4839-
dc.description.abstractTwo closely related phenyl selenyl based boron-di-pyrromethene (BODIPY) turn-on fluorescent probes for the detection of hypochlorous acid (HOCl) were synthesized for studies in chemical biology; emission intensity is modulated by a photoinduced electron-transfer (PET) process. Probe 2 intrinsically shows a negligible background signal; however, after reaction with HOCl, chemical oxidation of selenium forecloses the PET process, which evokes a significant increase in fluorescence intensity. The fluorescence intensity of probes 1 and 2 with HOCl involves an similar to 18 and similar to 50-fold enhancement compared with the respective responses from other reactive oxygen/nitrogen species (ROS/RNS) and low detection limits (30.9 nM for 1 and 4.5 nM for 2). Both probes show a very fast response with HOCl; emission intensity reached a maximum within 1 s. These probes show high selectivity for HOCl, as confirmed by confocal microscopy imaging when testing with RAW264.7 and MCF-7 cells (c) 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.description.uri1-
dc.language영어-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectbiosensing-
dc.subjectBODIPY-
dc.subjectfluorescence-
dc.subjecthypochlorous acid-
dc.subjectphotoinduced electron transfer-
dc.titleEnhanced Fluorescence Turn-on Imaging of Hypochlorous Acid in Living Immune and Cancer Cells-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000380271400028-
dc.identifier.scopusid2-s2.0-84973141721-
dc.identifier.rimsid62508ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorSandip V. Mulay-
dc.contributor.affiliatedAuthorYoungsam Kim-
dc.contributor.affiliatedAuthorDavid G. Churchill-
dc.identifier.doi10.1002/chem.201601270-
dc.identifier.bibliographicCitationCHEMISTRY-A EUROPEAN JOURNAL, v.22, no.28, pp.9642 - 9648-
dc.citation.titleCHEMISTRY-A EUROPEAN JOURNAL-
dc.citation.volume22-
dc.citation.number28-
dc.citation.startPage9642-
dc.citation.endPage9648-
dc.date.scptcdate2018-10-01-
dc.description.wostc21-
dc.description.scptc22-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusHUMAN ATHEROSCLEROTIC LESIONS-
dc.subject.keywordPlusINDUCED HOCL PRODUCTION-
dc.subject.keywordPlusSELECTIVE DETECTION-
dc.subject.keywordPlusRUTHENIUM(II) COMPLEX-
dc.subject.keywordPlusNEUTROPHIL PHAGOSOME-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusREACTIVE OXYGEN-
dc.subject.keywordPlusBODIPY DYES-
dc.subject.keywordPlusLIVE CELLS-
dc.subject.keywordPlusPROBE-
dc.subject.keywordAuthorbiosensing-
dc.subject.keywordAuthorBODIPY-
dc.subject.keywordAuthorfluorescence-
dc.subject.keywordAuthorhypochlorous acid-
dc.subject.keywordAuthorphotoinduced electron transfer-
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
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