IBS Publications Repository: Enhanced Fluorescence Turn-on Imaging of Hypochlorous Acid in Living Immune and Cancer Cells

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IBS Publications RepositoryCenter for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단)1. Journal Papers (저널논문)

Enhanced Fluorescence Turn-on Imaging of Hypochlorous Acid in Living Immune and Cancer Cells

DC Field	Value	Language
dc.contributor.author	Sandip V. Mulay	-
dc.contributor.author	Minsuk Choi	-
dc.contributor.author	Yoon Jeong Jang	-
dc.contributor.author	Youngsam Kim	-
dc.contributor.author	Sangyong Jon	-
dc.contributor.author	David G. Churchill	-
dc.date.available	2018-07-18T02:09:37Z	-
dc.date.created	2018-03-15	-
dc.date.issued	2016-07	-
dc.identifier.issn	0947-6539	-
dc.identifier.uri	https://pr.ibs.re.kr/handle/8788114/4839	-
dc.description.abstract	Two closely related phenyl selenyl based boron-di-pyrromethene (BODIPY) turn-on fluorescent probes for the detection of hypochlorous acid (HOCl) were synthesized for studies in chemical biology; emission intensity is modulated by a photoinduced electron-transfer (PET) process. Probe 2 intrinsically shows a negligible background signal; however, after reaction with HOCl, chemical oxidation of selenium forecloses the PET process, which evokes a significant increase in fluorescence intensity. The fluorescence intensity of probes 1 and 2 with HOCl involves an similar to 18 and similar to 50-fold enhancement compared with the respective responses from other reactive oxygen/nitrogen species (ROS/RNS) and low detection limits (30.9 nM for 1 and 4.5 nM for 2). Both probes show a very fast response with HOCl; emission intensity reached a maximum within 1 s. These probes show high selectivity for HOCl, as confirmed by confocal microscopy imaging when testing with RAW264.7 and MCF-7 cells (c) 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim	-
dc.description.uri	1	-
dc.language	영어	-
dc.publisher	WILEY-V C H VERLAG GMBH	-
dc.subject	biosensing	-
dc.subject	BODIPY	-
dc.subject	fluorescence	-
dc.subject	hypochlorous acid	-
dc.subject	photoinduced electron transfer	-
dc.title	Enhanced Fluorescence Turn-on Imaging of Hypochlorous Acid in Living Immune and Cancer Cells	-
dc.type	Article	-
dc.type.rims	ART	-
dc.identifier.wosid	000380271400028	-
dc.identifier.scopusid	2-s2.0-84973141721	-
dc.identifier.rimsid	62508	ko
dc.date.tcdate	2018-10-01	-
dc.contributor.affiliatedAuthor	Sandip V. Mulay	-
dc.contributor.affiliatedAuthor	Youngsam Kim	-
dc.contributor.affiliatedAuthor	David G. Churchill	-
dc.identifier.doi	10.1002/chem.201601270	-
dc.identifier.bibliographicCitation	CHEMISTRY-A EUROPEAN JOURNAL, v.22, no.28, pp.9642 - 9648	-
dc.citation.title	CHEMISTRY-A EUROPEAN JOURNAL	-
dc.citation.volume	22	-
dc.citation.number	28	-
dc.citation.startPage	9642	-
dc.citation.endPage	9648	-
dc.date.scptcdate	2018-10-01	-
dc.description.wostc	21	-
dc.description.scptc	22	-
dc.description.journalClass	1	-
dc.description.journalRegisteredClass	scie	-
dc.description.journalRegisteredClass	scopus	-
dc.subject.keywordPlus	HUMAN ATHEROSCLEROTIC LESIONS	-
dc.subject.keywordPlus	INDUCED HOCL PRODUCTION	-
dc.subject.keywordPlus	SELECTIVE DETECTION	-
dc.subject.keywordPlus	RUTHENIUM(II) COMPLEX	-
dc.subject.keywordPlus	NEUTROPHIL PHAGOSOME	-
dc.subject.keywordPlus	OXIDATIVE STRESS	-
dc.subject.keywordPlus	REACTIVE OXYGEN	-
dc.subject.keywordPlus	BODIPY DYES	-
dc.subject.keywordPlus	LIVE CELLS	-
dc.subject.keywordPlus	PROBE	-
dc.subject.keywordAuthor	biosensing	-
dc.subject.keywordAuthor	BODIPY	-
dc.subject.keywordAuthor	fluorescence	-
dc.subject.keywordAuthor	hypochlorous acid	-
dc.subject.keywordAuthor	photoinduced electron transfer	-