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나노입자 연구단
나노입자 연구단
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Inside Cover: Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment (Angew. Chem. Int. Ed. 38/2017)

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Title
Inside Cover: Ceria–Zirconia Nanoparticles as an Enhanced Multi-Antioxidant for Sepsis Treatment (Angew. Chem. Int. Ed. 38/2017)
Author(s)
Min Soh; Kang D.-W.; Jeong H.-G.; Kim Dokyoon; Kim D.Y.; Yang W.; Changyeong Song; Seungmin Baik; Choi I.-Y.; Ki S.-K.; Hyek Jin Kwon; Taeho Kim; Kim C.K.; Lee S.-H.; Taeghwan Hyeon
Publication Date
2017-09
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.56, no.38, pp.11399 - 11403
Publisher
WILEY-V C H VERLAG GMBH
Abstract
The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+, play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2 @ and COH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria–zirconia nanoparticles (CZ NPs) that possess a higher Ce3+/Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7Zr0.3O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases. (c) 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
URI
https://pr.ibs.re.kr/handle/8788114/4231
ISSN
1433-7851
Appears in Collections:
Center for Nanoparticle Research(나노입자 연구단) > Journal Papers (저널논문)
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