Reactive-Oxygen-Species-Responsive Drug Delivery Systems: Promises and Challenges Highly Cited Paper

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Title
Reactive-Oxygen-Species-Responsive Drug Delivery Systems: Promises and Challenges
Author(s)
Gurusamy Saravanakumar; Jihoon Kim; Won Jong Kim
Publication Date
2017-01
Journal
Advanced Science, v.4, no.1, pp.1600124 -
Publisher
Wiley
Abstract
Given the increasing evidence indicates that many pathological conditions are associated with elevated reactive oxygen species (ROS) levels, there have been growing research efforts focused on the development of ROS-responsive carrier systems because of their promising potential to realize more specific diagnosis and effective therapy. By judicious utilization of ROS-responsive functional moieties, a wide range of carrier systems has been designed for ROS-mediated drug delivery. In this review article, insights into design principle and recent advances on the development of ROS-responsive carrier systems for drug delivery applications are provided alongside discussion of their in vitro and in vivo evaluation. In particular, the discussions in this article will mainly focus on polymeric nanoparticles, hydrogels, inorganic nanoparticles, and activatable prodrugs that have been integrated with diverse ROS-responsive moieties for spatiotemporally controlled release of drugs for effective therapy. © 2016 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinhei
URI
https://pr.ibs.re.kr/handle/8788114/3381
ISSN
2198-3844
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
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