Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(I) complexes in A549 lung cancer cells
DC Field | Value | Language |
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dc.contributor.author | Arambula, JF | - |
dc.contributor.author | McCall, R | - |
dc.contributor.author | Sidoran, KJ | - |
dc.contributor.author | Magda, D | - |
dc.contributor.author | Mitchell, NA | - |
dc.contributor.author | C. W. Bielawski | - |
dc.contributor.author | Lynch, VM | - |
dc.contributor.author | Sessler, JL | - |
dc.contributor.author | Arumugam, K | - |
dc.date.available | 2016-03-07T06:36:35Z | - |
dc.date.created | 2016-02-19 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | https://pr.ibs.re.kr/handle/8788114/2406 | - |
dc.description.abstract | Ferrocene containing N-heterocyclic carbene (NHC) ligated gold(I) complexes of the type [Au(NHC)(2)](+) were prepared and found to be capable of regulating the formation of reactive oxygen species (ROS) via multiple mechanisms. Single crystal X-ray analysis of bis(1-(ferrocenylmethyl)-3-mesitylimidazol-2-ylidene)-gold(I) chloride (5) and bis(1,3-di(ferrocenylmethyl)imidazol-2-ylidene)-gold(I) chloride (6) revealed a quasi-linear geometry around the gold(I) centers (i.e., the C-Au-C bond angle were measured to be similar to 177 degrees and all the Au-C-carbene bonds distances were in the range of 2.00 (7)-2.03 (1) angstrom). A series of cell studies indicated that cell proliferation inhibition and ROS generation were directly proportional to the amount of ferrocene contained within the [Au(NHC)(2)](+) complexes (IC50 of 6 < 5 < bis(1-benzyl-3-mesitylimidazol-2-ylidene)-gold(I) chloride (4)). Complexes 4-6 were also confirmed to inhibit thioredoxin reductase as inferred from lipoate reduction assays and increased chelatable intracellular zinc concentrations. RNA microarray gene expression assays revealed that 6 induces endoplasmic reticulum stress response pathways as a result of ROS increase. © The Royal Society of Chemistry 2016 | - |
dc.description.uri | 1 | - |
dc.language | 영어 | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.title | Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(I) complexes in A549 lung cancer cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.identifier.wosid | 000368835300051 | - |
dc.identifier.scopusid | 2-s2.0-84961383314 | - |
dc.identifier.rimsid | 22339 | ko |
dc.date.tcdate | 2018-10-01 | - |
dc.contributor.affiliatedAuthor | C. W. Bielawski | - |
dc.identifier.doi | 10.1039/c5sc03519h | - |
dc.identifier.bibliographicCitation | CHEMICAL SCIENCE, v.7, no.2, pp.1245 - 1256 | - |
dc.citation.title | CHEMICAL SCIENCE | - |
dc.citation.volume | 7 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 1245 | - |
dc.citation.endPage | 1256 | - |
dc.date.scptcdate | 2018-10-01 | - |
dc.description.wostc | 21 | - |
dc.description.scptc | 23 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | ANTICANCER AGENTS SYNTHESIS | - |
dc.subject.keywordPlus | INDUCE OXIDATIVE STRESS | - |
dc.subject.keywordPlus | THIOREDOXIN REDUCTASE | - |
dc.subject.keywordPlus | MOTEXAFIN GADOLINIUM | - |
dc.subject.keywordPlus | ANTITUMOR-ACTIVITY | - |
dc.subject.keywordPlus | ANTIPROLIFERATIVE ACTIVITY | - |
dc.subject.keywordPlus | FERROCENIUM DERIVATIVES | - |
dc.subject.keywordPlus | PALLADIUM COMPLEXES | - |
dc.subject.keywordPlus | IONIZING-RADIATION | - |
dc.subject.keywordPlus | SANDWICH COMPLEXES | - |