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bielawsk,christopherw
다차원탄소재료연구단
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Targeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(I) complexes in A549 lung cancer cells

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dc.contributor.authorArambula, JF-
dc.contributor.authorMcCall, R-
dc.contributor.authorSidoran, KJ-
dc.contributor.authorMagda, D-
dc.contributor.authorMitchell, NA-
dc.contributor.authorC. W. Bielawski-
dc.contributor.authorLynch, VM-
dc.contributor.authorSessler, JL-
dc.contributor.authorArumugam, K-
dc.date.available2016-03-07T06:36:35Z-
dc.date.created2016-02-19-
dc.date.issued2016-02-
dc.identifier.issn2041-6520-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/2406-
dc.description.abstractFerrocene containing N-heterocyclic carbene (NHC) ligated gold(I) complexes of the type [Au(NHC)(2)](+) were prepared and found to be capable of regulating the formation of reactive oxygen species (ROS) via multiple mechanisms. Single crystal X-ray analysis of bis(1-(ferrocenylmethyl)-3-mesitylimidazol-2-ylidene)-gold(I) chloride (5) and bis(1,3-di(ferrocenylmethyl)imidazol-2-ylidene)-gold(I) chloride (6) revealed a quasi-linear geometry around the gold(I) centers (i.e., the C-Au-C bond angle were measured to be similar to 177 degrees and all the Au-C-carbene bonds distances were in the range of 2.00 (7)-2.03 (1) angstrom). A series of cell studies indicated that cell proliferation inhibition and ROS generation were directly proportional to the amount of ferrocene contained within the [Au(NHC)(2)](+) complexes (IC50 of 6 < 5 < bis(1-benzyl-3-mesitylimidazol-2-ylidene)-gold(I) chloride (4)). Complexes 4-6 were also confirmed to inhibit thioredoxin reductase as inferred from lipoate reduction assays and increased chelatable intracellular zinc concentrations. RNA microarray gene expression assays revealed that 6 induces endoplasmic reticulum stress response pathways as a result of ROS increase. © The Royal Society of Chemistry 2016-
dc.description.uri1-
dc.language영어-
dc.publisherROYAL SOC CHEMISTRY-
dc.titleTargeting antioxidant pathways with ferrocenylated N-heterocyclic carbene supported gold(I) complexes in A549 lung cancer cells-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000368835300051-
dc.identifier.scopusid2-s2.0-84961383314-
dc.identifier.rimsid22339ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorC. W. Bielawski-
dc.identifier.doi10.1039/c5sc03519h-
dc.identifier.bibliographicCitationCHEMICAL SCIENCE, v.7, no.2, pp.1245 - 1256-
dc.citation.titleCHEMICAL SCIENCE-
dc.citation.volume7-
dc.citation.number2-
dc.citation.startPage1245-
dc.citation.endPage1256-
dc.date.scptcdate2018-10-01-
dc.description.wostc21-
dc.description.scptc23-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPlusANTICANCER AGENTS SYNTHESIS-
dc.subject.keywordPlusINDUCE OXIDATIVE STRESS-
dc.subject.keywordPlusTHIOREDOXIN REDUCTASE-
dc.subject.keywordPlusMOTEXAFIN GADOLINIUM-
dc.subject.keywordPlusANTITUMOR-ACTIVITY-
dc.subject.keywordPlusANTIPROLIFERATIVE ACTIVITY-
dc.subject.keywordPlusFERROCENIUM DERIVATIVES-
dc.subject.keywordPlusPALLADIUM COMPLEXES-
dc.subject.keywordPlusIONIZING-RADIATION-
dc.subject.keywordPlusSANDWICH COMPLEXES-
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Center for Multidimensional Carbon Materials(다차원 탄소재료 연구단) > 1. Journal Papers (저널논문)
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