BROWSE

Related Scientist

synapse's photo.

synapse
시냅스뇌질환연구단
more info

ITEM VIEW & DOWNLOAD

Mice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference

DC Field Value Language
dc.contributor.authorSu-Yeon Choi-
dc.contributor.authorKihoon Han-
dc.contributor.authorTyler Cutforth-
dc.contributor.authorWoosuk Chung-
dc.contributor.authorHaram Park-
dc.contributor.authorDongsoo Lee-
dc.contributor.authorRyunhee Kim-
dc.contributor.authorMyeong-Heui Kim-
dc.contributor.authorYeeun Choi-
dc.contributor.authorKang Shen-
dc.contributor.authorEunjoon Kim-
dc.date.available2016-01-07T09:12:17Z-
dc.date.created2015-09-08-
dc.date.issued2015-07-
dc.identifier.issn1662-5102-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1958-
dc.description.abstractSynaptic adhesion molecules regulate diverse aspects of neuronal synapse development, including synapse specificity, formation, and maturation. Neph2, also known as Kirrel3, is an immunoglobulin superfamily adhesion molecule implicated in intellectual disability, neurocognitive delay associated with Jacobsen syndrome, and autism spectrum disorders. We here report mice lacking Neph2 (Neph2-/- mice) display moderate hyperactivity in a familiar, but not novel, environment and defective novel object recognition with normal performances in Morris water maze spatial learning and memory, contextual fear conditioning and extinction, and pattern separation tests. These mice also show normal levels of anxiety-like behaviors, social interaction, and repetitive behaviors. At the synapse level, Neph2-/- dentate gyrus granule cells exhibit unaltered dendritic spine density and spontaneous excitatory synaptic transmission. These results suggest that Neph2 is important for normal locomotor activity and object recognition memory. © 2015 FRONTIERS IN CELLULAR NEUROSCIENCE Choi, Han, Cutforth, Chung, Park, Lee, Kim, Kim, Choi, Shen and Kim-
dc.description.uri1-
dc.language영어-
dc.publisherFRONTIERS RES FOUND-
dc.subjectAutism spectrum disorder-
dc.subjectCognition-
dc.subjectHyperactivity-
dc.subjectIntellectual disability-
dc.subjectMemory-
dc.subjectSynaptic adhesion-
dc.subjectSynaptic transmission-
dc.titleMice lacking the synaptic adhesion molecule Neph2/Kirrel3 display moderate hyperactivity and defective novel object preference-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000358792000001-
dc.identifier.scopusid2-s2.0-84940184047-
dc.identifier.rimsid20959ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorDongsoo Lee-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.doi10.3389/fncel.2015.00283-
dc.identifier.bibliographicCitationFRONTIERS IN CELLULAR NEUROSCIENCE, v.9, no.JULY, pp.283-
dc.citation.titleFRONTIERS IN CELLULAR NEUROSCIENCE-
dc.citation.volume9-
dc.citation.numberJULY-
dc.citation.startPage283-
dc.date.scptcdate2018-10-01-
dc.description.wostc9-
dc.description.scptc8-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordAuthorAutism spectrum disorder-
dc.subject.keywordAuthorCognition-
dc.subject.keywordAuthorHyperactivity-
dc.subject.keywordAuthorIntellectual disability-
dc.subject.keywordAuthorMemory-
dc.subject.keywordAuthorSynaptic adhesion-
dc.subject.keywordAuthorSynaptic transmission-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
2015_123.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse