BROWSE

Related Scientist

li,yan's photo.

li,yan
시냅스뇌질환연구단
more info

ITEM VIEW & DOWNLOAD

Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning

DC Field Value Language
dc.contributor.authorHanwool Park-
dc.contributor.authorJinhee Yang-
dc.contributor.authorRyunhee Kim-
dc.contributor.authorYan Li-
dc.contributor.authorYeunkum Lee-
dc.contributor.authorChungwoo Lee-
dc.contributor.authorJongil Park-
dc.contributor.authorDongmin Lee-
dc.contributor.authorHun Kim-
dc.contributor.authorEunjoon Kim-
dc.date.available2016-01-07T09:10:13Z-
dc.date.created2015-12-07-
dc.date.issued2015-11-
dc.identifier.issn2045-2322-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/1845-
dc.description.abstractProtein ubiquitination has a significant influence on diverse aspects of neuronal development and function. Dorfin, also known as Rnf19a, is a RING finger E3 ubiquitin ligase implicated in amyotrophic lateral sclerosis and Parkinson's disease, but its in vivo functions have not been explored. We report here that Dorfin is a novel binding partner of the excitatory postsynaptic scaffolding protein PSD-95. Dorfin-mutant (Dorfin-/-) mice show reduced adult neurogenesis and enhanced long-term potentiation in the hippocampal dentate gyrus, but normal long-term potentiation in the CA1 region. Behaviorally, Dorfin-/- mice show impaired contextual fear conditioning, but normal levels of cued fear conditioning, fear extinction, spatial learning and memory, object recognition memory, spatial working memory, and pattern separation. Using a proteomic approach, we also identify a number of proteins whose ubiquitination levels are decreased in the Dorfin-/- brain. These results suggest that Dorfin may regulate adult neurogenesis, synaptic plasticity, and contextual fear memory-
dc.description.uri1-
dc.language영어-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleMice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000364385500002-
dc.identifier.scopusid2-s2.0-84946950124-
dc.identifier.rimsid21761ko
dc.date.tcdate2018-10-01-
dc.contributor.affiliatedAuthorYan Li-
dc.contributor.affiliatedAuthorYeunkum Lee-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.doi10.1038/srep16410-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, v.5, pp.16410 - 16410-
dc.citation.titleSCIENTIFIC REPORTS-
dc.citation.volume5-
dc.citation.startPage16410-
dc.citation.endPage16410-
dc.date.scptcdate2018-10-01-
dc.description.wostc9-
dc.description.scptc10-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
2015_125.pdfDownload

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse