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Poly(norepinephrine): Ultrasmooth Material-Independent Surface Chemistry and Nanodepot for Nitric Oxide

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Title
Poly(norepinephrine): Ultrasmooth Material-Independent Surface Chemistry and Nanodepot for Nitric Oxide
Author(s)
Seonki Hong; Jihoon Kim; Yun Suk Na; Junghong Park; Sunjin Kim; Kaushik Singha; Gun-Il Im; Dong-Keun Han; Won Jong Kim; Haeshin Lee
Publication Date
2013-08
Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.52, no.35, pp.9187 - 9191
Publisher
WILEY-V C H VERLAG GMBH
Abstract
Norepinephrine (NE) is a small-molecule catecholamine which has a variety of functions in the body. The most important function of NE is its role as a neurohormone and neurotransmitter for controlling responsiveness to stress and fear (Figure 1, bottom).[1] In addition to its use in the brain, NE is also released into the bloodstream to maintain heart rate and blood pressure.[2] Catecholamines are also found in underwater living creatures, such as mussels. The adhesive foot proteins in mussels are catecholamine-rich proteins in which the catechol is derived from a side chain of 3,4- dihydroxy-l-phenylalanine (DOPA; Figure 1, top), and the amine is a side chain of the basic amino acid lysine. Thus, the robust adhesion of mussels shares an interesting chemical similarity with a variety of other biological functions in neurons.
URI
https://pr.ibs.re.kr/handle/8788114/1580
ISSN
1433-7851
Appears in Collections:
Center for Self-assembly and Complexity(복잡계 자기조립 연구단) > Journal Papers (저널논문)
Files in This Item:
2013-08-26-Angewandte-Poly(norepinephrine) Ultrasmooth Material-Independent Surface Chemistry and Nanodepot for Nitric Oxide.pdfDownload

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