BROWSE

Related Scientist

heejin,cho's photo.

heejin,cho
시냅스뇌질환연구단
more info

ITEM VIEW & DOWNLOAD

Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits

DC Field Value Language
dc.contributor.authorHeejin Cho-
dc.contributor.authorTaesun Yoo-
dc.contributor.authorMoon, Heera-
dc.contributor.authorKang, Hyojin-
dc.contributor.authorYang, Yeji-
dc.contributor.authorKang, MinSoung-
dc.contributor.authorYang, Esther-
dc.contributor.authorLee, Dowoon-
dc.contributor.authorHwang, Daehee-
dc.contributor.authorKim, Hyun-
dc.contributor.authorKim, Doyoun-
dc.contributor.authorKim, Jin Young-
dc.contributor.authorEunjoon Kim-
dc.date.accessioned2023-11-13T22:01:08Z-
dc.date.available2023-11-13T22:01:08Z-
dc.date.created2023-07-17-
dc.date.issued2023-08-
dc.identifier.issn1359-4184-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/14135-
dc.description.abstractADNP syndrome, involving the ADNP transcription factor of the SWI/SNF chromatin-remodeling complex, is characterized by developmental delay, intellectual disability, and autism spectrum disorders (ASD). Although Adnp-haploinsufficient (Adnp-HT) mice display various phenotypic deficits, whether these mice display abnormal synaptic functions remain poorly understood. Here, we report synaptic plasticity deficits associated with cognitive inflexibility and CaMKIIα hyperactivity in Adnp-HT mice. These mice show impaired and inflexible contextual learning and memory, additional to social deficits, long after the juvenile-stage decrease of ADNP protein levels to ~10% of the newborn level. The adult Adnp-HT hippocampus shows hyperphosphorylated CaMKIIα and its substrates, including SynGAP1, and excessive long-term potentiation that is normalized by CaMKIIα inhibition. Therefore, Adnp haploinsufficiency in mice leads to cognitive inflexibility involving CaMKIIα hyperphosphorylation and excessive LTP in adults long after its marked expressional decrease in juveniles. © 2023, The Author(s).-
dc.language영어-
dc.publisherSpringer Nature-
dc.titleAdnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid001020368700006-
dc.identifier.scopusid2-s2.0-85162865323-
dc.identifier.rimsid81157-
dc.contributor.affiliatedAuthorHeejin Cho-
dc.contributor.affiliatedAuthorTaesun Yoo-
dc.contributor.affiliatedAuthorEunjoon Kim-
dc.identifier.doi10.1038/s41380-023-02129-5-
dc.identifier.bibliographicCitationMolecular Psychiatry, v.28, no.8, pp.3548 - 3562-
dc.relation.isPartOfMolecular Psychiatry-
dc.citation.titleMolecular Psychiatry-
dc.citation.volume28-
dc.citation.number8-
dc.citation.startPage3548-
dc.citation.endPage3562-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaNeurosciences & Neurology-
dc.relation.journalResearchAreaPsychiatry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryNeurosciences-
dc.relation.journalWebOfScienceCategoryPsychiatry-
dc.subject.keywordPlusDEPENDENT NEUROPROTECTIVE PROTEIN-
dc.subject.keywordPlusLONG-TERM POTENTIATION-
dc.subject.keywordPlusPOSTSYNAPTIC DENSITY-95-
dc.subject.keywordPlusAUTISM-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusCHROMATIN-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusMUTATIONS-
dc.subject.keywordPlusSYNGAP-
dc.subject.keywordPlusLTD-
Appears in Collections:
Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse