BROWSE

Related Scientist

mannkyu,hong's photo.

mannkyu,hong
분자활성촉매반응연구단
more info

ITEM VIEW & DOWNLOAD

Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-beta aggregation and toxicity

DC Field Value Language
dc.contributor.authorDu, Zhi-
dc.contributor.authorNam, Eunju-
dc.contributor.authorLin, Yuxi-
dc.contributor.authorMannkyu Hong-
dc.contributor.authorMolnar, Tamas-
dc.contributor.authorKondo, Ikufumi-
dc.contributor.authorIshimori, Koichiro-
dc.contributor.authorMu-Hyun Baik-
dc.contributor.authorLee, Young-Ho-
dc.contributor.authorLim, Mi Hee-
dc.date.accessioned2023-08-02T22:01:07Z-
dc.date.available2023-08-02T22:01:07Z-
dc.date.created2023-05-30-
dc.date.issued2023-05-
dc.identifier.issn2041-6520-
dc.identifier.urihttps://pr.ibs.re.kr/handle/8788114/13687-
dc.description.abstractCytochrome c (Cyt c), a multifunctional protein with a crucial role in controlling cell fate, has been implicated in the amyloid pathology associated with Alzheimer's disease (AD); however, the interaction between Cyt c and amyloid-beta (A beta) with the consequent impact on the aggregation and toxicity of A beta is not known. Here we report that Cyt c can directly bind to A beta and alter the aggregation and toxicity profiles of A beta in a manner that is dependent on the presence of a peroxide. When combined with hydrogen peroxide (H2O2), Cyt c redirects A beta peptides into less toxic, off-pathway amorphous aggregates, whereas without H2O2, it promotes A beta fibrillization. The mechanisms behind these effects may involve a combination of the complexation between Cyt c and A beta, the oxidation of A beta by Cyt c and H2O2, and the modification of Cyt c by H2O2. Our findings demonstrate a new function of Cyt c as a modulator against A beta amyloidogenesis.-
dc.language영어-
dc.publisherRoyal Society of Chemistry-
dc.titleUnveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-beta aggregation and toxicity-
dc.typeArticle-
dc.type.rimsART-
dc.identifier.wosid000980883900001-
dc.identifier.scopusid2-s2.0-85159049525-
dc.identifier.rimsid80874-
dc.contributor.affiliatedAuthorMannkyu Hong-
dc.contributor.affiliatedAuthorMu-Hyun Baik-
dc.identifier.doi10.1039/d3sc00881a-
dc.identifier.bibliographicCitationChemical Science, v.14, no.20, pp.5340 - 5349-
dc.relation.isPartOfChemical Science-
dc.citation.titleChemical Science-
dc.citation.volume14-
dc.citation.number20-
dc.citation.startPage5340-
dc.citation.endPage5349-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalClass1-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusCYTOCHROME-C RELEASE-
dc.subject.keywordPlusMETAL-BINDING-
dc.subject.keywordPlusALZHEIMERS-
dc.subject.keywordPlusPEPTIDE-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusOLIGOMERS-
dc.subject.keywordPlusDISEASE-
dc.subject.keywordPlusSTRESS-
Appears in Collections:
Center for Catalytic Hydrocarbon Functionalizations(분자활성 촉매반응 연구단) > 1. Journal Papers (저널논문)
Files in This Item:
There are no files associated with this item.

qrcode

  • facebook

    twitter

  • Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse