Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses
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Title
- Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses
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Author(s)
- Hyejung Won; Won Mah; Eun Joon Kim
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Publication Date
- 2013-08
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Journal
- FRONTIERS IN MOLECULAR NEUROSCIENCE, v.6, pp.19
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Publisher
- FRONTIERS MEDIA SA
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Abstract
- Autism spectrum disorder (ASD) is a group of developmental disabilities characterized by impairments in social interaction and communication and restricted and repetitive interests/behaviors. Advances in human genomics have identified a large number of genetic variations associated with ASD. These associations are being rapidly verified by a growing number of studies using a variety of approaches, including mouse genetics. These studies have also identified key mechanisms underlying the pathogenesis of ASD, many of which involve synaptic dysfunctions, and have investigated novel, mechanism-based therapeutic strategies. This review will try to integrate these three key aspects of ASD research: human genetics, animal models, and potential treatments. Continued efforts in this direction should ultimately reveal core mechanisms that account for a larger fraction of ASD cases and identify neural mechanisms associated with specific ASD symptoms, providing important clues to efficient ASD treatment.
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URI
- https://pr.ibs.re.kr/handle/8788114/1269
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DOI
- 10.3389/fnmol.2013.00019
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ISSN
- 1662-5099
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Appears in Collections:
- Center for Synaptic Brain Dysfunctions(시냅스 뇌질환 연구단) > 1. Journal Papers (저널논문)
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